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KEAP1
Name
Name
Kelch-like ECH-Associated Protein 1
Relevant Pathway
Relevant Pathway
Function
Function
Suppresses Nrf2 activity by sequestering in the cytoplasm and targeting for proteasomal degradation. Also functions as sensor of oxidant and electrophiles
Role in Longevity
Role in Longevity
Keap1 loss-of-function mutations extend lifespan of Drosophila males
Reference
Reference
Sykiotis (2008)
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