Epigallocatechin-3-gallate
Chemical Formula: C22H18O11
Exact Mass: 458.08 g/mol
Molecular Weight: 458.4 g/mol
Elemental Analysis: C(57.65%) H(3.96%) O(38.40%)
SMILES: C1[C@H]([C@H](OC2=CC(=CC(=C21)O)O)C3=CC(=C(C(=C3)O)O)O)OC(=O)C4=CC(=C(C(=C4)O)O)O
PubChem CID: 65064
Chemical Structure:
Alternative Names
EGCG
Source
Green tea
Protein Target/Signalling
AMPK
EP300
PGC‐1α
FOXO3a
Biological Pathway
mTOR
IGF/IIS
Lipid metabolism
Epigenetic modification
Longevity-Related Effects/Anti-ageing mechanism
Potential senolytic
Lifespan extension in rats
AMPK activation
HAT inhibitor
HDACi
SASP modulation
FOXO3a activation
Biological Activity
Inhibition of human aortic smooth muscle cells proliferation by upregulation of mitofusin 2 by PGC‐1α/ERR‐α pathway, cardioprotective
Therapeutic potential in context of diabetic cardiomyopathy
Activation of Nrf2 signalling pathway to reduce formaldehyde-induce neurotoxicity in mice; suppression of premature senesence of preadipocytes by downregulation of PI3K/Akt/mTOR and AMPK signalling, and modulation of SASP by suppression of the accumulation of Bcl-2p
Lifespan extension in healthy rats via reduction of liver and kidney function damage and improved age-associated inflammation and oxidative stress
Activates FOXO3a to inhibit invasive phenotype of breast cancer cells
Reference
Dato (2016), Choi (2009), Vazirian (2018), Shu (2018), Santos (2018), Al Hroob (2019), Huang (2019), He 2018), Kumar (2019), Niu (2013), Belguise (2007)