Embedded Files
JAK3
Name
Name
Janus kinase 3
Relevant Pathway
Relevant Pathway
Function
Function
Nociception
Stimulation releases neuropeptides, substance P to promote neurogenic inflammation and calcutonin gene-related peptide (CGRP) to antagonise insulin release in in vivo assays
Role in Longevity
Role in Longevity
JAK pathway inhibition suppresses SASP in senescent cells and alleviates age-related tissue dysfunction
Reference
Reference
Xu (2016), Rawlings (2004)
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