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Nicotinamide
Chemical Formula: C6H6N2O
Chemical Formula: C6H6N2O
Exact Mass: 122.05 g/mol
Exact Mass: 122.05 g/mol
Molecular Weight: 122.12 g/mol
Molecular Weight: 122.12 g/mol
Elemental Analysis: C(59.01%) H(4.95%) N(22.94%) O(13.10%)
Elemental Analysis: C(59.01%) H(4.95%) N(22.94%) O(13.10%)
SMILES: C1=CC(=CN=C1)C(=O)N
SMILES: C1=CC(=CN=C1)C(=O)N
PubChem CID: 936
Chemical Structure:
Alternative Names
Alternative Names
NAM
Vitamin B3
Source
Source
Milk
Beer
Endogenous
Protein Target/Signalling
Protein Target/Signalling
Sirtuins
PARPs
Biological Pathway
Biological Pathway
Epigenetic modification
Longevity-Related Effects/Anti-ageing mechanism
Longevity-Related Effects/Anti-ageing mechanism
Lifespan extension in C. elegans
NAD+ precursor
Sirtuin inhibitor
Biological Activity
Biological Activity
Amide form of niacin, precursor for NAD+. Sirtuins convert NAD+ into NAM, extends lifespan in C. elegans even in absence of sir-2.1. Maintenance of PARP integrity. Effective and widely used sirtuin inhibitor
Reference
Reference
Schmeisser (2013), Li (2006), Bonkowski (2016)
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