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Isoliquiritigenin
Chemical Formula: C15H12O4
Chemical Formula: C15H12O4
Exact Mass: 256.07 g/mol
Exact Mass: 256.07 g/mol
Molecular Weight: 256.25 g/mol
Molecular Weight: 256.25 g/mol
Elemental Analysis: C(70.31%) H(4.72%) O(24.97%)
Elemental Analysis: C(70.31%) H(4.72%) O(24.97%)
SMILES: C1=CC(=CC=C1/C=C/C(=O)C2=C(C=C(C=C2)O)O)O
SMILES: C1=CC(=CC=C1/C=C/C(=O)C2=C(C=C(C=C2)O)O)O
PubChem CID: 638278
Chemical Structure:
Alternative Names
Alternative Names
Source
Source
Liquorice
Protein Target/Signalling
Protein Target/Signalling
SIRT1
DAF-1/FOXO
SKN-1/Nrf2
Biological Pathway
Biological Pathway
Epigenetic modification
IGF/IIS
Antioxidant signalling
Inflammation
Longevity-Related Effects/Anti-ageing mechanism
Longevity-Related Effects/Anti-ageing mechanism
Activator of Sirt1
Biological Activity
Biological Activity
Improves insulin resistance in high-fat fed mice
Exerts antioxidant activity through activating transcription factors DAF-1/FOXO and SKN-1/Nrf2
Attenuates oxidative stress-induced injuries via Nrf2-ARE signalling pathway after traumatic brain injury in mice
Alleviation of Ang II-induced hypertensive renal injury via Nrf2 and NF-κB pathways in HK-2 cells
Reference
Reference
Peng (2015), Lee (2018a), Link (2019), Zhang (2018a), Xiong (2018), Howitz (2003)
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