• NOD-, LRR- and pyrin domain-containing protein 3

• Inflammation

• Major sensor for intracellular damage-associated molecular patterns (DAMPs). Activated by ROS and other danger signals, activating inflammatory caspase-1 for the cleavage of IL-1β and IL-18 for the stimulation of subsequent secretion

• Key inflammasome in inflammaging 

Salminen (2012b)