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NF-κB
Name
Name
Nuclear factor kappa-light-chain-enhancer of activated B cells
Relevant Pathway
Relevant Pathway
Function
Function
Cytoplasmic sensor system to internal and external signals, i.e. pathogens, oxidative stress, hypoxia, and genotoxic stress; five structurally related members: NF-κB1 (p50), NF-κB2 (p52), RelA (p65), RelB, and c-Rel
Role in Longevity
Role in Longevity
Genetic and pharmacological inhibition of NF-κB signalling prevents age-associated features in progeroid mice models
Pharmacological inhibition extends lifespan of Drosophila melanogaster males and females
Inhibited by downstream targets of AMPK e.g. SIRT1, PGC-1α, p53, and FOXO
Reference
Reference
López-Otín (2013), Osorio (2012), Salminen (2011), Moskalev (2011), Liu (2017)
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