Curcumin
Chemical Formula: C21H20O6
Exact Mass: 368.13 g/mol
Molecular Weight: 368.4 g/mol
Elemental Analysis: C(68.47%) H(5.47%) O(26.06%)
SMILES: COC1=C(C=CC(=C1)/C=C/C(=O)CC(=O)/C=C/C2=CC(=C(C=C2)O)OC)O
PubChem CID: 969516
Chemical Structure:
Alternative Names
Diferuloylmethane
Source
Tumeric
Protein Target/Signalling
AMPK
NF-κB
AP-1
HO-1
SOD
Biological Pathway
mTOR
IGF/IIS
Epigenetic modification
Inflammation
Antioxidant signalling
Longevity-Related Effects/Anti-ageing mechanism
Lifespan extension in Drosophila
Somatic cell reprogramming, multiple effects on STAT, HDACi
AMPK activator
Enhances cardioprotective effect of metformin in type I diabetes via Nrf2/HO-1 and JAK/STAT pathways in vivo
Biological Activity
Mimics neurocognitive and anti-inflammatory effects of CR in midlife obese mice
Hepatoprotective
Hepatoprotective against proplthiouracil-induced liver injury in rats
Lifespan extension in Drosophila via regulating expression of SOD and reducing accumulation of malondialdehyde and lipid peroxidation
Reference
Chen (2011), Sarker (2015), Salem (2014), Xiao (2018), Wojcik (2018), Khan (2019), Bunker (2019), Abdelsamia (2019), Shen (2013)