Embedded Files
α-ketoglutarate
Chemical Formula: C5H4O5-2
Chemical Formula: C5H4O5-2
Exact Mass: 144.01 g/mol
Exact Mass: 144.01 g/mol
Molecular Weight: 144.08 g/mol
Molecular Weight: 144.08 g/mol
Elemental Analysis: C(41.68%) H(2.80%) O(55.52%)
Elemental Analysis: C(41.68%) H(2.80%) O(55.52%)
SMILES: C(CC(=O)[O-])C(=O)C(=O)[O-]
SMILES: C(CC(=O)[O-])C(=O)C(=O)[O-]
PubChem CID: 164533
Chemical Structure:
Alternative Names
Alternative Names
Source
Source
Tricarboxykuc acid (TCA) cycle metabolite
Protein Target/Signalling
Protein Target/Signalling
AMPK
mTOR
Biological Pathway
Biological Pathway
Inflammation
mTOR
Longevity-Related Effects/Anti-ageing mechanism
Longevity-Related Effects/Anti-ageing mechanism
Lifespan extension in ageing mice, lifespan extension in Drosophila
Reduction of inflammation, AMPK activation, mTOR inhibition
Biological Activity
Biological Activity
Reduction of chronic inflammation and induction of IL-10, leading to reduced frailty and enhanced longevity in ageing mice
Inhibition of mTOR and activation of AMPK for lifespan extension in Drosophila
Reference
Reference
Asadi Shahmirzadi (2020), Su (2019)
Page updated
Google Sites
Report abuse