SREL Reprint #3659

Is CpG density the link between epigenetic aging and lifespan?

Emily M. Bertucci1,2 and Benjamin B. Parrott1,2

1Savannah River Ecology Laboratory, Aiken, SC 29802, USA
2Eugene P. Odum School of Ecology, University of Georgia, Athens, GA 30602, USA

Abstract: The genetic mechanisms contributing to lifespan variation remain unresolved. Based on recent conceptual advances in our understanding of epigenetic potential and the relocalization of chromatin modifiers (RCM), we hypothesize that increased CpG density is protective against age-related erosion of the epigenetic landscape and may explain interspecific variation in lifespan.

SREL Reprint #3659

Bertucci, E. M. and B. B. Parrott. 2020. Is CpG density the link between epigenetic aging and lifespan? Trends in Genetics 36(10): 725-727.

This information was provided by the University of Georgia's Savannah River Ecology Laboratory (srel.uga.edu).