Research Profiles:

1. ORCID : 0000-0002-6232-1665

2. Researcher ID : D-7288-2015

3. Scopus ID : 56912454400

4. Kudos : 143802

5. Publons : a/995244/

6. Google Scholar : Arunaksharan Narayanankutty

7. Researchgate : Arunaksharan Narayanankutty

JOURNAL EDITORSHIP

1. Guest Editor, Horticulturae (2021). Traditional Herbal Medicines in the Management of Health and Agriculture. (https://www.mdpi.com/journal/horticulturae/special_issues/traditional_herbal_medicines). Impact Factor: 2.331 (SCI/PubMed/Medline/Scopus Indexed)

2. Guest Editor, Recent Patents on Anti-cancer Drug Discovery (2020). Metal nanoparticles as emerging drug candidates in the management of cancers and microbial infectious diseases. (BMS-PRA-2021-HT-4). Impact Factor: 4.610 (SCI/PubMed/Medline/Scopus Indexed)

3. Guest Editor, Current Drug Targets (2020). Targeting carcinogenesis and cancer progression by Natural products. (BMS-CDT-2020-HT-31). Impact Factor: 3.465 (SCI/PubMed/Medline/Scopus Indexed)

RESEARCH PROJECTS

1. Chemical composition, antioxidant, antiinflammatory, and anticancer properties of the essential oils from Ocimum basilicum, O. gratissimum, O. tenuiflorum and O. canum. Kerala State Council for Science, Technology and Environment (2020-2021). Letter No. 00784/SPS65/2021/KSCSTE Dt: 23.12.2021. Role: Principal Investigator

2. Effect of the Coconut (Cocos nucifera) and Palmyra palm (Borassus flabellifer) haustorium extract on Sodium fluoride induced cytotoxicity and its molecular mechanism of action. Kerala State Council for Science, Technology and Environment (2020-2021). Letter No. 01029/SPS64/2019/KSCSTE Dt: 23.12.2021. Role: Principal Investigator

3. A study on the phytochemical content and anticancer activity of methanolic extract of Azima tetracantha leaves. Kerala State Council for Science, Technology and Environment (2019-2020). Letter No. 01519/SPS64/2019/KSCSTE Dt: 16.02020. Role: Principal Investigator

4. Study on the Phenolic constituents and anticancer activity of Amaranthus viridis, A. spinosus and A. dubius. Kerala State Council for Science, Technology and Environemnt (2019-2020). Letter No. 01476/SPS64/2019/KSCSTE Dt: 16.01.2020. Role: Principal Investigator

5. Study on the Antioxidant, anti-inflammatory and anticancer activities of Thottea siliquosa. RUSA- St. Joseph’s College (Autonomous), Devagiri (2019-2020). Role: Co- Investigator

Publications

1. Sneha K.; Narayanankutty, A.; Job, J.T.; Olatunji, O.J.; Alfarhan, A.; Famurewa, A.C.; Ramesh, V. Antimicrobial and Larvicidal Activities of Different Ocimum Essential Oils Extracted by Ultrasound-Assisted Hydrodistillation. Molecules 2022, 27, 1456. Impact factor: 4.412. https://doi.org/10.3390/molecules27051456

2. Kim YO, Narayanankutty A, Kuttithodi AM, Kim HJ, Na SW, Kunnath K, Rajagopal R, Alfarhan A. Azima tetracantha Leaf Methanol Extract Inhibits Gastric Cancer Cell Proliferation through Induction of Redox Imbalance and Cytochrome C Release. Applied Sciences. 2022; 12:1: 120. Impact factor: 2.679 https://doi.org/10.3390/app12010120

3. Narayanankutty A, Sasidharan A, Job JT, Rajagopal R, Alfarhan A, Kim YO, Kim HJ. Mango ginger (Curcuma amada Roxb.) rhizome essential oils as source of environmental friendly biocides: Comparison of the chemical composition, antibacterial, insecticidal and larvicidal properties of essential oils extracted by different methods. Environmental Research. 2021; 202:111718.Impact factor: 6.498 https://doi.org/10.1016/j.envres.2021.111718

4. Tom A., Job JT, Rajagopal R, Alfarhan A, Kim H-J, Ock Kim Y, Won Na S, Narayanankutty A. Thottea siliquosa (Lam.) Ding Hou leaf methanolic extract inhibits lipopolysaccharide-induced TLR4 activation and cytokine production as well as ethyl methyl sulfonate induced genotoxicity. Physiological and Molecular Plant Pathology 2021: 101772. Impact factor: 2.747. https://doi.org/10.1016/j.pmpp.2021.101772

5. Job JT, Rajagopal R, Alfarhan A, Ramesh V, Narayanankutty A. Toxic effects of fluoride in intestinal epithelial cells and the mitigating effect of methanol extract of coconut haustorium by enhancing de novo glutathione biosynthesis. Environmental Research 2021. 200:111717. Impact factor: 6.498 https://doi.org/10.1016/j.envres.2021.111717

6. Kim H-J, Narayanankutty A, Sasidharan A, Tom Job J, Ock Kim Y, Won Na S, Rajagopal R, Alfarhan A, Al-Munqedhi B (2021) Methanolic extract of coconut (Cocos nucifera L.) haustorium mitigates pro-oxidant-mediated apoptotic cell death via Nrf-2 pathway and lipopolysaccharide-induced cytokine release in cells Journal of King Saud University - Science:101715. (Published ahead of Print) Impact factor: 4.011. https://doi.org/10.1016/j.jksus.202101715

7. Narayanankutty A, Kunnath K, Famurewa AC, Ramesh V, Rajagopal R, Alfarhan A (2021) Variations in the composition, cytoprotective and anti-inflammatory effects of natural polyphenols of edible oils extracted from fresh and dried coconut testa Physiological and Molecular Plant Pathology:10174 Impact factor: 747. https://doi.org/10.1016/j.pmpp.2021.101742

8. Narayanankutty. A, Aswathi MK, Alfarhan A., Rajagopal R., Barcelo D. Chemical composition of Allspice (Pimenta dioica) essential oil and its insecticidal and mosquito larvicidal activities. Molecules. 26, 6698. Impact factor: 4.411. https://doi.org/10.3390/molecules26216698

9. Anusmitha KM, Aruna M, Job JT, Narayanankutty A, Pb B, Rajagopal R, Alfarhan A, Barcelo D (2021) Phytochemical analysis, antioxidant, anti-inflammatory, anti-genotoxic and anticancer activities of different ocimum plant extracts prepared by ultrasound-assisted method Physiological and Molecular Plant Pathology:101746. Impact factor: 2.747. https://doi.org/10.1016/j.pmpp.2021.101746

10. Narayanankutty. A, Kunnath K, Alfarhan A., Rajagopal R., Ramesh V (2021). Chemical composition of Cinnamomum verum leaf and flower essential oils and analysis of their antibacterial, insecticidal, and larvicidal properties. Molecules. Impact factor: 4.411. https://doi.org/10.3390/molecules26206303

11. Suseela I.M., Narayanankutty A., Smitha K R, Jeksy J M, Vipin P S, Shaji E M, Ramya M K, Padikkala J, and A C Raghavamenon (2021). Desmodium gyrans DC modulates lipid trafficking in cultured macrophages and improves functional HDL in male Wistar rats. Indian Journal of Pharmacology (Accepted). Impact factor: 1.200. https://pubmed.ncbi.nlm.nih.gov/34414906/

12. Illam S.P., Kandiyil S.P., Narayanankutty, A., Veetil S.V., Babu T.D., Uppu R.M., Raghavamenon A.C. (2021). Virgin coconut oil complements with its polyphenol components mitigate sodium fluoride toxicity in vitro and in vivo. Drug and Chemical Toxicology, Impact factor: 3.356. https://doi.org/10.1080/01480545.2021.1926476

13. Narayanankutty, A., Krishnaprasad K., Jose B., Ramesh V., Rajagopal R., Alfarhan A. (2021). Analysis of the chemical composition of root essential oil from Indian Sarsaparilla (Hemidesmus indicus) and application as ecofriendly insecticide and pharmacological agent. Saudi Journal of Biological Sciences, (Accepted). Impact factor: 4.219. https://doi.org/10.1016/j.sjbs.2021.0028

14. Malayil, D., Jose B., Narayanankutty, A., Ramesh V., Rajagopal R., Alfarhan A. (2021). Phytochemical profiling of Azima tetracantha Lam. leaf methanol extract and elucidation of its potential as a chain-breaking antioxidant, anti-inflammatory and anti-proliferative agent. Saudi Journal of Biological Sciences, (Accepted). Impact factor: 4.219. https://doi.org/10.1016/j.sjbs.2021.07.090

15. Narayanankutty, A. (2021). Pharmacological potentials and Nutritional values of Tropical and Sub-tropical Fruits of India: Emphasis on their anticancer bioactive components. Recent Patents on Anti-Cancer Drug Discovery. Impact factor: 4.169. https://doi.org/10.2174/1574892816666211130165200

16. Narayanankutty A., (2021). Inhibitory Potential of Dietary Nutraceuticals on Cellular PI3K/Akt Signaling: Implications in Cancer Prevention and Therapy. Current Topics in Medicinal Chemistry (Epub). https://doi.org/10.2174/1568026621666210716152224

17. Job J.T., Rajagopal R., Alfarhan A., Kim Y., Kim H.J., Narayanankutty, A., (2021). Protective effect of Borassus flabellifer haustorium extract against alkoxyl radical-induced cytotoxicity by improving glutathione metabolism by modulating Nrf2/Haeme oxygenase-1 expression. Journal of the American College of Nutrition, https://doi.org/10.1080/07315724.2021.1942313

18. Job, J.T., Rajagopal R., Alfarhan A., Narayanankutty, A., (2021). Borassus flabellifer Linn haustorium methanol extract mitigates fluoride-induced apoptosis by enhancing Nrf2/Haeme oxygenase 1 –dependent glutathione metabolism in intestinal epithelial cells. Drug and Chemical Toxicology, https://doi.org/10.1080/01480545.2021.1926476

19. Illam S.P., Narayanankutty A, Kandiyil S.P., and Raghavamenon A C (2021). Variations in natural polyphenols determine the anti-inflammatory potential of virgin coconut oils. Journal of Food Science, https://doi.org/10.1111/1750-3841.15705

20. Koottasseri A., Babu A., Augustine A., Job, JT., Narayanankutty A. (2021). Antioxidant, Anti-Inflammatory and Anticancer Activities of Methanolic Extract of Thottea siliquosa: An In Vitro and In Silico Study. Recent Patents on Anti-Cancer Drug Discovery https://doi.org/10.2174/1574892816666210401143750

21. Narayanankutty A. (2021). Natural Products as PI3K/ Akt Inhibitors: Implications in Preventing Hepatocellular Carcinoma. Current Molecular Pharmacology 15. https://doi.org/10.2174/1874467214666210120152657

22. Malayil, D., House, N.C., Puthenparambil, D., Job, J.T., Narayanankutty, A., (2020). Borassus flabellifer haustorium extract prevents pro-oxidant mediated cell death and LPS-induced inflammation. Drug and Chemical Toxicology, 1-7. https://doi.org/10.1080/01480545.2020.1858854

23. Sathyan A.M., Asifa K.P., Narayanankutty A. (2020). Natural bioactive compounds in preventing breast cancer: Role of phytoestrogens. Current Drug Targets (E-Pub). https://doi.org/10.2174/1389450121999201109215341

24. Narayanankutty A., Kuzhivelil B.T., Raghavamenon AC (2020). A high-fructose diet formulated with thermally oxidized monounsaturated fat aggravates metabolic dysregulation in colon epithelial tissues of rats. Journal of the American College of Nutrition (Ahead of Print) https://doi.org/10.1080/07315724.2020.1846145

25. Narayanankutty A., Illam SP., Rao V., Shehabudheen S., Raghavamenon AC (2020). Hot-processed virgin coconut oil abrogates cisplatin-induced nephrotoxicity by restoring redox balance in rats compared to fermentation-processed virgin coconut oil. Drug and Chemical Toxicology (Ahead of Print) https://doi.org/10.1080/01480545.201831525

26. Narayanankutty A. (2020). Phytochemicals as PI3K/ Akt/ mTOR Inhibitors and Their Role in Breast Cancer Treatment. Recent Patents on Anti-Cancer Drug Discovery 15. https://doi.org/10.2174/1574892815666200910164641

27. Cheerakuzhy House N.C., Puthenparampil D., Malayil D., Narayanankutty A., (2020). Variation in the polyphenol composition, antioxidant and anticancer activity among different Amaranthus species. South African Journal of Botany 135: 408-412. https://doi.org/10.1016/j.sajb.2020.09.026

28. Narayanankutty A., Sasidharan A., and Job JT (2020). Targeting Toll like Receptors in Cancer: Role of TLR natural and synthetic modulators. Current Pharmaceutical Design (Ahead of Print). https://doi.org/10.2174/1381612826666200720235058

29. Narayanankutty A., Nair A., Illam SP., Upaganlawar A., Raghavamenon AC (2020). Curcumin enriched VCO protects against 7, 12-Dimethyl Benz [a] anthracene-induced skin papilloma in mice. Nutrition and Cancer: An International Journal (Ahead of Print) https://doi.org/10.1080/01635581.2020.1778745

30. Illam S.P., Hussain A, Elizabeth A, Narayanankutty A. Raghavamenon AC (2019). Natural combination of phenolic glycosides from fruits resists pro-oxidant insults to colon cells and enhances intrinsic antioxidant status in mice. Toxicological Reports 18;6:703-711. https://doi.org/10.1016/j.toxrep.2019.07.005

31. Narayanankutty A. (2019). PI3K/Akt/mTOR pathway as a therapeutic target for colorectal cancer: A review of preclinical and clinical evidence. Current Drug Targets 20 (12), 1217-12 https://doi.org/10.2174/1389450120666181211111815

32. Sheela, D.L., Narayanankutty A, Nazeem P.A., Raghavamenon A C., Shylaja M. R. (2019). Lauric acid induces cell death in colon cancer cells mediated by the Epidermal Growth Factor Receptor downregulation: An In silico and In vitro study. Human and Experimental Toxicology 38(7): 753-761. https://doi.org/10.1177/096032711983918

33. Narayanankutty A. (2019). Toll like receptors as a novel therapeutic target for natural products against degenerative disorders. Current Drug Targets 20 (10), 1068-1080. https://doi.org/10.2174/1389450120666190222181506

34. Narayanankutty A, Job T.J., Narayanankutty V (2019). Glutathione, an antioxidant tripeptide: Dual roles in Carcinogenesis and Chemoprevention. Current Protein & Peptide Science 20(9): 907-917. https://doi.org/10.2174/1389203720666190206130003

35. Narayanankutty V, Narayanankutty A, Nair A (2018). Heat shock proteins (HSPs): A novel target for cancer metastasis prevention. Current Drug Targets 20(7):727-737. https://doi.org/10.2174/1389450120666181211111815

36. Narayanankutty A, Anil A, Illam S.P., Kandiyil S.P., and Raghavamenon A C (2018). Non-polar lipid carbonyls of thermally oxidized coconut oil induce hepatotoxicity mediated by redox imbalance. Prostaglandins, Leukotrienes and Essential Fatty Acids (PLEFA), 138: 45-51. https://doi.org/10.1016/j.plefa.2018.10.004

37. Narayanankutty A., S.P. Illam, & Raghavamenon A.C. (2018) Health impacts of different edible oils prepared from coconut (Cocos nucifera): A comprehensive review. Trends in Food Science & Technology. 80: 1-7. https://doi.org/10.1016/j.tifs.2018.07.025

38. Narayanankutty A., Gopinath MK, Vakayil M, Ramavarma SK, Babu TD and Raghavamenon AC (2018), Non-enzymatic conversion of primary oxidation products of Docosahexaenoic acid into less toxic acid molecules. Spectrochimica Acta Part A: Molecular and Biomolecular Spectroscopy. 203: 222-228. https://doi.org/10.1016/j.saa.2018.05.082

39. Narayanankutty A., Palliyil D.M., Kuruvilla K. and A. C Raghavamenon (2017) Virgin coconut oil reverses hepatic steatosis by restoring redox homeostasis and lipid metabolism in male Wistar rats. Journal of the Science of Food and Agriculture, 98(5):1757-1764. https://doi.org/10.1002/jsfa.8650

40. Roy N., Nazeem P. A., Babu T. D., Abida P. S., Narayanankutty, A., Valsalan R., Valsala P. A., and Raghavamenon A. C. (2017). EGFR gene regulation in colorectal cancer cells by garlic phytocompounds with special emphasis on S-Allyl-L-Cysteine Sulfoxide. Interdisciplinary Sciences: Computational Life Sciences https://doi.org/10.1007/s12539-017-0227-6

41. Lekshmi Sheela, D., Abdulla Nazeem P, Narayanankutty A, Shylaja Muthangaparambil R, Davis S P, James P, Valsalan R, Devassy Babu T and Raghavamenon A C (2017). Coconut phytocompounds inhibits polyol pathway enzymes: Implication in prevention of microvascular diabetic complications. Prostaglandins, Leukotrienes and Essential Fatty Acids (PLEFA), 127: 20-24 https://doi.org/10.1016/j.plefa.2017.1010.1004

42. Illam S.P., Narayanankutty A., E.M. Shaji, V. Remya, M. Rosemol & A.C. Raghavamenon (2017) Epithelial Mesenchymal Transition in Cancer Progression: Preventive Phytochemicals. Recent Patents on Anti-Cancer Drug Discovery 12 (3): 234-246. https://doi.org/10.2174/1574892812666170424150407

43. Illam S.P., Narayanankutty A., & A.C. Raghavamenon (2017) Polyphenols of Virgin coconut oil prevent pro-oxidant mediated cell death. Toxicology Mechanism and Methods 27(6):442-450. https://doi.org/10.1080/15376516.2017.1320458

44. Mukundan S. and Narayanankutty A. (2017) Traditional Fruits of Kerala: Bioactive Compounds and their Curative Potential in Chronic Diseases. Current Nutrition & Food Science. 13(4): 279- 289. https://doi.org/10.2174/1573401313666170206164643

45. Narayanankutty A., Anagha K., Shaji E.M., Illam S.P., Suseela I.M. and Achuthan C Raghavamenon (2017) Vitamin E supplementation modulates the effect of Omega 3 fatty acids treatment in aged rats, Toxicology Mechanisms and Methods, 27(3): 207-214 https://doi.org/101080/15376516.2016.1273431

46. Narayanankutty A., Jeksy J. M., Suseela I.M., Smitha K. R., Shaji E. M., Illam S.P., Babu T.D., Balu T. K. and Raghavamenon A.C. (2017) Deep fried edible oils disturbs hepatic redox equilibrium and heightens lipotoxicity and hepatosteatosis in rats. Human and Experimental Toxicology 36 (9): 919-930. https://doi.org/10.1177/0960327116674530

47. Lekshmi D.S., Nazeem P.A., Narayanankutty A., Jeksy J.M., and Raghavamenon A.C. (2016) In Silico and Wet Lab Studies Reveal the Cholesterol Lowering Efficacy of Lauric Acid a Medium Chain Fat of Coconut Oil. Plant Foods for Human Nutrition, 71 (4): 410-415 https://doi.org/10.1007/s11130-016-0577-y

48. Narayanankutty A., Muneera V, Jeksy J.M., Smitha K.R., Indu M. Suseela, Babu T.D. and Raghavamenon A.C. (2016) Omega 3 fatty acids: Do they raise health concerns? JSM Biochemistry and Molecular biology, 3(1): 1016.

49. Roy N., Narayanankutty A., Nazeem P. A., Valsalan R, Babu T. D. and Mathew D. (2016) Plant phenolics ferulic acid and p-coumaric acid inhibits colorectal cancer cell proliferation by through EGFR down regulation. Asian Pacific Journal of Cancer Prevention 17(8): 4017-4021. https://pubmed.ncbi.nlm.nih.gov/27644655/

50. Roy N., Davis S., Narayanankutty A., Nazeem P.A., Babu T. D., Abida P.S., Valsala P.A., Raghavamenon A. C. (2016). Garlic phytocompounds possess anticancer activity by specifically targeting breast cancer biomarkers: An In silico study. Asian Pacific Journal of Cancer Prevention 17(6): 2883-2888. https://pubmed.ncbi.nlm.nih.gov/27356707/

51. Narayanankutty A., Reshma K. M., Shabna K. A., Smitha K. R., Indu M. S., Jeksy J. M., Balu T. K. and Achuthan C. Raghavamenon (2016). Virgin coconut oil maintains redox status and improves glycemic conditions in high fructose fed rats. Journal of food science and technology, 53 (1): 895-901. https://doi.org/10.1007/s13197-015-2040-8

52. Jeksy J.M., Indu M. S., Smitha K. R., Narayanankutty A. and Achuthan C. Raghavamenon (2015). Component Authentication and Standardisation of an Anti-atherosclerotic Herbal Formulation-GSTC3. Pharmacognosy Journal, 7 (6): 339-343. http://dx.doi.org/10.5530/pj.2015.6.4

Presentations:

1. Arunaksharan Narayanankutty, Soorya PI, Balu T K and Achuthan C. Raghavamenon. “Thermally oxidized edible oils enhance hepatosteatosis in male Wistar rats by inducing redox imbalance and pro-inflammatory insults”. 36^th Annual Convention of Indian Association of Cancer Research, Thrissur, February 09-11, 2017.

2. Arunaksharan Narayanankutty, Soorya PI, Balu T K and Achuthan C. Raghavamenon. “Thermally oxidized edible oil rich in polyunsaturated fats disturbs hepatic redox equilibrium and heightens hepatic steatosis in rats”. 12^th International Conference of Asian Clinical Oncologist Society and 35^th Annual Convention of Indian Association of Cancer Research, New Delhi, April 08-10, 2016.

3. Arunaksharan Narayanankutty, Jeksy J M, Balu T K and Achuthan C. Raghavamenon. “Prolonged consumption of thermally oxidized dietary fats induces hyperglycemia and alters oxidative homeostasis in the Colonic epithelium”. 6^th International Translational Cancer Research Conference- Prevention and Treatment of Cancer: Hypes and Hopes, Ahmedabad, February 04-07, 2016.

4. Devika Mukundan, Ramya M K, Arunaksharan Narayanankutty, Indu M S, Shaji E M, Kezia Kuruvilla, Achuthan C. Raghavamenon. Virgin coconut oil alleviates non-alcoholic hepatic steatosis in Wistar Rats. 28^th Kerala Science Congress, January 27-30, 2016.

5. Arunaksharan Narayanankutty, Midhun K G, Shelsa K. James and Achuthan C. Raghavamenon. “Molecules generated from oxidized DHA and EPA induces carbonyl stress and cytotoxicity in cellular milieu.” Recent developments in cancer biology, Pazhassiraja College, Sultan Battery, 22-24 July, 2015.

6. Arunaksharan Narayanankutty, Smitha K R, Indu M S, Jeksy M J and Achuthan C. Raghavamenon. “Thermally oxidized coconut oil fed rats are more susceptible to changes associated with hepatic steatosis than fresh oil.” National conference on advances in laboratory practices, M.E.S. College, Perinthalmanna, 14-15 June, 2015.

7. Arunaksharan Narayanankutty, K M Reshma and Achuthan C. Raghavamenon. “Virgin coconut oil as fatty acid source in high fructose diet reduces hyperglycemia and oxidative stress in Wistar rats”. 27^th Kerala Science Congress, Alappuzha, 28-30 January, 2015.

8. Arunaksharan Narayanankutty, Shweta Mukundan, George Mathew and Jomy John. A Preliminary Ecological Study of Azhingillam Wetlands with Special Emphasis on Water Fowl Fauna. Proceedings of the National Conference on Modern Trends in Zoological Research. St. Aloysius College, Elthuruth, 25-26 March, 2014.