SARS-CoV vs SARS-CoV-2

Alignment File for SARS-Cov Spike Protein sequence with SARS-CoV-2 Spike Protein sequence: File found here

Dr Norimatsu has created PDB files for 6acg Soluble (Possible broken link) (SARS-CoV) and 6m17 Soluble (Possible broken link) (SARS-CoV-2) and also the structural alignment (Possible broken link) between the two.

(PyMOL command: "align 6m17 and resi 21-51, 6acg and resi 21-51").

Video

Amino Acid Difference between SARS-CoV and SARS-CoV-2 (Reference)

table completed by EF

SARS-CoV Spike Protein + ACE2 (6ACG)

Chains A, B, and C are part of the spike glycoprotein

Chain D belongs of ACE-2

table completed by EF

SARS-CoV-2 RBD + CR3022 Antibody (6W41)

Heterotrimer

Chain C is the spike glycoprotein RBD

Chain H is Fab heavy chain

Chain L is Fab light chain

Chain A/H: Antibody heavy chain

Chain B/L: Antibody light chain

Chain C/C: SARS-CoV-2 spike protein RBD

Information on carbonyl-carbonyl interactions here.

Table completed by AH

Table verified by EF