In 1900, about 40% of US jobs were in agriculture, and a substantial fraction of economic activity required hard physical labor. Workers' strength and physical stamina were key job skills. Today, cognitive skills are valued in the US, and workers with college degrees earn about double that of those without college degrees. The premium on graduate school education is even higher than that of undergraduate education. What is important is not education per se but skills you gain. These are traditionally literacy, numeracy and problem-solving skills like those measured by PIAAC. However, the rise of artificial intelligence (AI) will place premium on more abstract skills like the ability to discover truths and to understand how the world works. These are the skills required to apply science and technologies to address the needs and wants of human beings (like helping people achieve good health outcomes). The most powerful combination is the understanding of hard sciences and humanities. This kind of understanding (general intelligence) cannot be achieved by AI in the foreseeable future. Your ultimate challenge is to gain the kinds of cognitive skills required to address the issues you care about. My goal is to combine big data, machine learning, molecular biology and causal structure discovery to understand how thousands of different types of cells in the human body function and to apply this understanding to create new medical therapies. Can you understand my wants (scientific discovery and publication of research findings) and help me with your understanding of science and technologies?