Absolute Interaction Energy Data

sACE2 with SARS-CoV-2 receptor binding domain

(sace2-rbd, 595+223 amino acids)

Wild Type (wt)

Mutations: None.

Procko-v2 (pv2)

Mutations: T27Y, L79T, N330Y, A386L.

Norimatsu-s1 (ns1)

Mutations: K31Y, F40D, T92P, R393K, R518G.

Norimatsu-s2 (ns2)

Mutations: Q24T, N33D, W69V, Q76T, Q89P.

Norimatsu-s3 (ns3)

Mutations: L29F, Y41R, F72Y, L91P, T324P.

Norimatsu-s4 (ns4)

Mutations: A25V, L39R, N90Q, L351F, P389D.

Norimatsu-s5 (ns5)

Mutations: K26D, H34P, Q42L, E75K, Q325P.

sACE2 decoy with SARS-CoV-2 receptor binding domain

(rg-rbd, 62+223 amino acids)

Wild Type (wt)

Mutations: None.

Norimatsu-d1 (nd1)

Mutations: K31Y, F40D

Norimatsu-d2 (nd2)

Mutations: Q24T, N33D, W69V

Norimatsu-d3 (nd3)

Mutations: L29F, Y41R, F72Y

Norimatsu-d4 (nd4)

Mutations: A25V, L39R, Q76T

Norimatsu-d5 (nd5)

Mutations: K26D, Q42L, E75K

Norimatsu-d6 (nd6)

Mutations: T27Y, H34P, L79T