TSS

Staphylococcal Toxic Shock Syndrome

Definition: Most often is associated with colonization of surgical wounds, burns, vagnitis, or tampon use in young women; cases are also seen after nasal packing for epistaxis.

Dx: fever, hypotension, mucosal hyperemia, macular desquamating erythroderma of the palms and soles, and multisystem involvement, such as vomiting, diarrhea, or multiorgan failure.

Definition: TSS is a life-threatening systemic disease caused by exotoxin super antigens produced by S. aureus or group A beta-hemolytic Streptococcus (GABHS) tissue infection.

Streptococcal Toxic Shock Syndrome

Associated with invasive GABHS infections, particularly necrotizing fasciitis or myositis (80% of cases)

Dx: sudden onset of severe diffuse or localized pain. Systemic manifestations are otherwise similar to Staph TSS, but the desquamating erythroderma is much less common.

Dxtic: BC are usually positive and ASO titers are elevated.

Mortality: higher than Staph TSS.

Dxtic testing:

Lab: BC are usually negative. CPK is elevated. Detection of TSST-1 in that is indicates protection against recurrence.

Mortality is relatively low.