Phenytoin dosing/interactions
Drugs that increase Phenytoin levels:
Amiodarone
Cimetidine
Fluoxetine
Omeprazole
Oxacarbazepine
Ticlodipine
Phenytoin decrease drug levels:
Amiodarone
BB
Corticosteroids
Fluconazole
Fluoxetine
Itraconazole
OCP
PIs
Warfarin
Phenytoin toxicity
- therapeutic range (10 - 20 mcg/mL)
- nystagmus on far lateral gaze
- blurred vision, diplopia, ataxia, slurred speech, dizziness, drowsiness, coma.
Refer phenytoin flow chart