Antiarrhythmics classification

Antiarrhythmia drug classification

• Class I: Na+ channel blockers

  • Ia: Quninidine, procainamide, disopyramide: prolong action potential (QPD)

  • Ib: Lidocaine, mexilitene, pheytoin: shorten action potential (LMP)

  • Ic: Flecainaide, morcizine, and propafenone

• Class II: ß-blockers: decreases sympathetic stimuli to heart. Propranolol, atenolol, metoprolol, esmolol, acebutolol

• Class III: K+ channel blockers: Bretylium, amiodarone, sotalol, ibitulide (BASI), dofetilide.

• Class IV: CCB: verapamil, diltazem, nifedipine, amlodipine

• Miscellaneous: Na+/K+ - ATPase inhibitors: Adenosine, digoxin.