Hyperammonemia - DDx

    • Reye's syndrome

    • GIB

    • UTI with a urease-producing organism (Proteus mirabilis)

    • Ureterosigmoidostomy

    • Shock

    • Severe muscle exertion/heavy exercise

    • Cigarette smoking

    • Transient hyperammonemia in newborns

    • Certain inborn errors of metabolism (urea cycle defects and organic acidemia)

    • Any cause of porto-systemic shunting of blood

    • Parenteral nutrition

    • After high-dose chemotherapy

    • Drugs such as:

      • Valproic acid

      • Barbiturates

      • Narcotics

      • Diuretics

      • Alcohol

    • Salicylate intoxication