PDMS microwell arrays for HTS of chemical library against cells

DATE CREATED:

Dec. 11th, 2008

ACTION PLAN

PROBLEMS IDENTIFIED (PI) / OUTSIDE SKILL REQUIRED (OSR) / RESOLVED (R)

PAPER TITLE

A) Background.

B) Specific Aims:

C) General Experimental Approach (Design etc):

D) Design Pitfalls and alternatives

E) Potential Figures:

F) Future Directions:

A) BACKGROUND:

microfabricated system for in vitro control of cell microenviroment and application for HTS

B) SPECIFIC AIMS

AIM 1 - reversible sealing PDMS microfluidic system for control interaction b/w cells and soluble materials.

AIM 2 - PEG

C) GENERAL EXPERIMENTAL APPROACH

PDMS sealing, PEG sealing. Hydrophobic, hydrophilic, covalent binding.

D) DESIGN PITFALLS AND ALTERNATIVES

E) POTENTIAL FIGURES FOR PAPER

scheme, cell life time, cell/materials pattern, materials release speed, cell-materials interaction

F) FUTURE DIRECTIONS

To expend materials sources: drug, growth factor, proteins.

To pattern two types of cells or more