Simultaneously Transporting and Heating Droplets by Thermoresistive and Dielectric Heating Integrated on an EWOD-Based Digital Microfludic Platform
整合熱電阻與介電質加熱法於介電濕潤數位微流體平台以實現微液滴同時加熱與操控
Microfluidic chips with a heating capability have been widely applied to biochemistry but transportation and heating of microfluidis were handled separately. To simplify chip design and miniaturize chip size, it is necessary to integrate heaters into a transporting system. In this thesis, based on the thermoresistive and dielectric heating, we successfully demonstrated droplets moved and heated simultaneously by the same electrode on a EWOD-based parallel-plate device.
The meander-line electrode was designed for the thermoresistive heating the bottom plate. The meander-line electrode is regarded as a heater when a DC power was applied at the two ends and as a traditional EWOD electrode when an AC signal was applied between it and th top plate. The droplet temperature was proportional to the supplied power. A 3.6 uL droplet could be heated to about 93oC when the applied power was 450 mW.
For the dielectric heating, the droplet manipulated in the parallel plates was moved when the frequency of the applied voltage was at 1 kHz and heated at 100 to 300 kHz. A 3.6 uL droplet was heated to about 80oC when the applied signal was 300 kHz and 120 Vrms. In addition, the droplet was moved and heated at same time by the signal mixed with a 1 kHz signal and a signal of the frequency heating the droplets.
[1] J.-H. Wei, W. Hsu and S.-K. Fan (January 2007). Realizing Temperature-Controlled Digital Microfluidic Chips with Versatile Microelectrodes, The 2nd Annual IEEE International Conference on Nano/Micro Engineered and Molecular Systems, Bangkok, Thailand.
[2] C.-P. Chiu, P.-W. Huang, S.-K. Fan, J.-H. Wei, and W. Hsu (May 2007). Reflective electronic-paper display utilizing electric polarized particle chains, Society for Information Display (SID) International Symposium, Long Beach, U.S.A..
[3] J.-H. Wei, W. Hsu, and S.-K. Fan (August 2007). Transporting and Heating Droplets by AC Electric Fields on a EWOD-Based Parallel Plate Device, The 1st IEEE International Conference on Nano/Molecular Medicine and Engineering, Macau, China.