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楊涵評 (Hanping Yang)
楊涵評 (Hanping Yang)
A digital microfluidic platform on flexible polymer films
A digital microfluidic platform on flexible polymer films
可撓式高分子基板應用於數位流體平台之研究
可撓式高分子基板應用於數位流體平台之研究
Digital microfluidic platform has been widely used in the biomedical analysis due to its advantages of simple configuration, no moving parts, and programmable control. Different from previous studies on hard substrate, flexible polymer films are proposed to develop the digital microfluidic device. First, in feasibility study, material and fabrication procresses are evaluated. The device tests and analytical analysis are performed in tilted and flat conditions. Also, droplet transportation on curved surface is successfully demonstrated. Second, a new principle of droplet actuation, asymmetric electrowetting, is studied. Due to charge trapping of insulator at different polarities, droplet can be actuated to oscillate on square coplanar electrodes. By using this phenomenon, unidirectional pumping of 1.0 ul droplet with a speed up to 23.6 mm/s is successfully demonstrated on asymmetric coplanar electrodes when a 100 Vp and 9 Hz square wave is applied. At last, a reusable and plug-and-play fluidic interface is designed for droplet interconnection. In gap size investigation and fluidic interface tests, feasibility of droplet crossing the interface gap and pumping across the fluidic interface are validated. Three modularized components are designed for 3-D microfluidic ring. Finally, 2.5 ul droplet is successfully transported at a speed of 105.7 mm/s when 120 VAC is applied.
Digital microfluidic platform has been widely used in the biomedical analysis due to its advantages of simple configuration, no moving parts, and programmable control. Different from previous studies on hard substrate, flexible polymer films are proposed to develop the digital microfluidic device. First, in feasibility study, material and fabrication procresses are evaluated. The device tests and analytical analysis are performed in tilted and flat conditions. Also, droplet transportation on curved surface is successfully demonstrated. Second, a new principle of droplet actuation, asymmetric electrowetting, is studied. Due to charge trapping of insulator at different polarities, droplet can be actuated to oscillate on square coplanar electrodes. By using this phenomenon, unidirectional pumping of 1.0 ul droplet with a speed up to 23.6 mm/s is successfully demonstrated on asymmetric coplanar electrodes when a 100 Vp and 9 Hz square wave is applied. At last, a reusable and plug-and-play fluidic interface is designed for droplet interconnection. In gap size investigation and fluidic interface tests, feasibility of droplet crossing the interface gap and pumping across the fluidic interface are validated. Three modularized components are designed for 3-D microfluidic ring. Finally, 2.5 ul droplet is successfully transported at a speed of 105.7 mm/s when 120 VAC is applied.
[1] H. Yang and W. Hsu (July 2002). Feasibility Study of Microfluidic Handling by Polar Capillary Effect, Pacific Rim Workshop on Transducers and Micro/Nano Technologies, Xiamen, China.
[1] H. Yang and W. Hsu (July 2002). Feasibility Study of Microfluidic Handling by Polar Capillary Effect, Pacific Rim Workshop on Transducers and Micro/Nano Technologies, Xiamen, China.
[2] H. Yang, S.-K. Fan, and W. Hsu (November 2005). 3D Droplet Transportation by EWOD Actuations on Flexible Polymer Films, ASME 2005 International Mechanical Engineering Congress and Exposition, Orlando, U.S.A..
[2] H. Yang, S.-K. Fan, and W. Hsu (November 2005). 3D Droplet Transportation by EWOD Actuations on Flexible Polymer Films, ASME 2005 International Mechanical Engineering Congress and Exposition, Orlando, U.S.A..
[3] S.-K. Fan, H. Yang, T.-T. Wang, and W. Hsu, "Asymmetric Electrowetting - Moving Droplets by a Square Wave." Lab on a Chip 2007, 7, 1330-1335.
[3] S.-K. Fan, H. Yang, T.-T. Wang, and W. Hsu, "Asymmetric Electrowetting - Moving Droplets by a Square Wave." Lab on a Chip 2007, 7, 1330-1335.
[4] H. Yang, W. Hsu, and S.-K. Fan (January 2008). Wristand-like droplet platform by digital microfluidic modulation, The 21th IEEE International Conference on Micro Electro Mechanical Systems, Tucson, U.S.A..
[4] H. Yang, W. Hsu, and S.-K. Fan (January 2008). Wristand-like droplet platform by digital microfluidic modulation, The 21th IEEE International Conference on Micro Electro Mechanical Systems, Tucson, U.S.A..
[5] H. Yang, S.-K. Fan, and W. Hsu (January 2008). Connecting interface for modularization of digital microfluidics, SPIE Symposium on MOEMS-MEMS, San Jose, U.S.A..
[5] H. Yang, S.-K. Fan, and W. Hsu (January 2008). Connecting interface for modularization of digital microfluidics, SPIE Symposium on MOEMS-MEMS, San Jose, U.S.A..
[6] S.-K. Fan, H. Yang and W. Hsu, “Droplet-on-a-Wristband: Chip-to-Chip Digital Microfluidic Interfacesbetween Replaceable and Flexible Electrowetting Modules.” Lab on a Chip 2011, 11, 343–347.
[6] S.-K. Fan, H. Yang and W. Hsu, “Droplet-on-a-Wristband: Chip-to-Chip Digital Microfluidic Interfacesbetween Replaceable and Flexible Electrowetting Modules.” Lab on a Chip 2011, 11, 343–347.
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