Journal Club (Lorena)

TCGA dimensionality reduction to recognize breast cancer subtypes

Comparison of Breast Cancer Molecular Features and Survival by African and European Ancestry in The Cancer Genome Atlas

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5671371

JAMA Oncol. 2017 Oct; 3(10): 1654–1662.

Published online 2017 Oct 12. Prepublished online 2017 May 4. doi: 10.1001/jamaoncol.2017.0595

Discussion

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PAM50 not discriminant enough.

Lorena relied on TCGA biolinks package (bioconductor)

Hackathon

• Tilling Apps

• Melanoma results

• Mutation signature project: https://analysistools-qa.cancer.gov/mutational-signatures

• epiDonate - Ideas to generate live API documenttion:
  https://smartbear.com
  https://documenter.getpostman.com/view/7490604/UVCCf44Q

• ...