2025-07-02 JUL

AlphaGenome
first impressions

Nature, 25 July 2025
www.nature.com/articles/d41586-025-01998-w
Tool aims to solve the mystery of non-coding sequences — but is still in its infancy, building on previous work, AlphaMissense, on coding regions.

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I could not find a REST API endpoint for AlphaGenome and Gemini confirms that it is not available ...
AlphaGenome is developed to complement two efforts targetting coding regions: "This model builds on our previous genomics model, Enformer and is complementary to AlphaMissense, which specializes in categorizing the effects of variants within protein-coding regions. These regions cover 2% of the genome. The remaining 98%, called non-coding regions, are crucial for orchestrating gene activity and contain many variants linked to diseases. AlphaGenome offers a new perspective for interpreting these expansive sequences and the variants within them."
for other Biology driven AI resourcs from deeppmind see https://deepmind.google/research/projects
See acknowledgments , it suggests that gRPC is being used.
Note supporting libraries, including support for gRPC in Javascript.
See architecture, below, and Gemini AI Studio Notebook.
Community: https://www.alphagenomecommunity.com.
I'm under the impression that a URL for a REST API endpoint is forthcoming. I'll be waiting with https://epiverse.github.io/alphaGen ...
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// call for gps coordinates
// https://mapsplatform.google.com/pricing

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