Journal Club (Wendy)

Nasirigerdeh, R., Torkzadehmahani, R., Matschinske, J. et al. sPLINK: a hybrid federated tool as a robust alternative to meta-analysis in genome-wide association studies. Genome Biol 23, 32 (2022). https://doi.org/10.1186/s13059-021-02562-1.

Notes from discussion:

• https://www.cog-genomics.org/plink, https://www.ncbi.nlm.nih.gov/pmc/articles/PMC1950838/

• https://arxiv.org/abs/2105.10545

• It looks like plink is developed in C++, can it be delivered via WASM?

• https://github.com/shijingc/TransMeta

Examples from the paper:

• https://github.com/TUM-AIMED/hyfed/blob/48c7ee0dda92ebb70cc985dc4c0eedb7403dc823/hyfed-docs/readme/develop_hyfed.md

• https://github.com/TUM-AIMED/splink/blob/main/splink-client/hyfed_client/project/hyfed_client_project.py

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Hackaton

Onboarding analysts to BigQuery

https://bigrquery.r-dbi.org

Show oauth2 in R

A. Keep this feature in mind: whcihever auth mechanism we onboard with Nicole's we'll onboard later everybody else

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B. Is IAM good? if not, should't we proxy service tokens with OAUTH2 to engage Connect vs Sharing service tolkens

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Daniel's analytics package for Connect: https://github.com/Analyticsphere/ConnectAnalystR

FAIR Smart APIs

https://smart-api.info
https://software.docs.hubmapconsortium.org/apis.html
https://smart-api.info/ui/5a6bea1158d2652743c7a201fdb1c44d