Ants engage in diverse interactions with organisms including microbes. Consequences following these interactions include, but not limited to, cohesive coevolutionary history. This seminar aims to explore research in my lab on the coevolutionary dynamics involving invasive ants and their interacting parasites and microbes. I will begin by talking about the dynamic defensive strategies of two invasive crazy ants - the longhorn crazy ant and yellow crazy ant - against kleptoparasites of varying virulence, followed by a case study highlighting the horizontal transmission of the Wolbachia endosymbiont driven by the close ecological relationships between the longhorn crazy ants and parasites. Then I will shift the focus to North America’s No 1 pest ant species, the odorous house ant, and discuss how the ant’s social organization shapes the diversity and prevalence of associated microbes. Finally, the seminar concludes with our recent findings on viral spillover occurring through myrmecophilous interactions.