UNLVGeo-genomic Mutational Atlas of Pathogens (GoMAP)
Sending medical providers a letter illustrating their unusually high drug prescribing rates in comparison with their peers had no measurable impact on prescription rates. As part of on-going efforts to reduce inappropriate prescribing of controlled substances, SBST and HHS’s Centers for Medicare and Medicaid Services (CMS) sent providers with unusually high billing patterns a letter comparing their prescribing rates with the prescribing rates of their peers, as well as educational information about proper prescribing practices. No measurable impact was seen on prescription rates. The null result has prompted further exploration into the design and timing of the communications, and new approaches are now being piloted.
UNLV Geo-genomic Mutational Atlas of Pathogens (GoMAP)
UNLV
Geo-genomic Mutational Atlas of Pathogens (GoMAP)
GOMOJO FUNDING AND CONDOM DISTRIBUTION OF GLOBAL FUNDING FOR HIV AIDS
GOMOJO
FUNDING AND CONDOM DISTRIBUTION OF GLOBAL FUNDING FOR HIV AIDS
We present a new approach for pathogen surveillance we call Geogenomics. Geogenomics examines the geographic distribution of the genomes of pathogens, with a particular emphasis on those mutations that give rise to drug resistance. We engineered a new web tool called Geogenomic Mutational Atlas of Pathogens (GoMAP) that enables investigation of the global distribution of individual drug resistance mutations. As a test case we examined mutations associated with HIV resistance to FDA-approved antiretroviral drugs. Approximately 40 million people are infected with HIV and one of the major limitations in HIV drug therapy is loss of effectiveness due to HIV acquiring or transmitting drug resistance mutations. The GoMAP-HIV makes use of existing public drug resistance and HIV protein sequence data to examine the distribution of 872 drug resistance mutations in ~502,000 sequences for many countries in the world. GoMAP also uses a broadened classification scheme for HIV drug resistance mutations. GoMAP-HIV is an open access web application available at gomap.bio-toolkit.com/GoMap/. GoMap was built by David Sargeant, Michael Hedden, and Sandeep Deverasetty, with contributions from Steve Schooler, Dr. Christy Strong, and ~25 undergraduate students in the Schiller lab
PLEASE CITE USE OF GoMap WITH THIS PAPER:
Sargeant DP et. al. (2014)The Geogenomic Mutational Atlas of Pathogens (GoMAP) Web System. PLoS One 9:e92877 PMID: 24675726