Stephen de Thorpe was born circa 1385 in Goxhill, Lincolnshire, England to Sir Stephen de Thorpe and Elizabeth Constable. He married Isabel Plumpton, daughter of Sir William Plumpton and Alice Gisburn on March 10, 1425. They had three sons:
1. Stephen de Thorpe b. circa 1410
2. William de Thorpe
3. Henry de Thorpe
Stephen de Thorpe died on March 12 in either 1441 or 1442.