The Vulcan race native to the Beta Quadrant of the milky way begin to mentally train themselves to suppress their emotions.
Tuchanka, the krogan homeworld, enters the nuclear age. In a global conflict, weapons of mass destruction are released, triggering a nuclear winter. In the resulting devastation, krogan society devolves into a collection of warring clans.
The Xindi-Avians build a concealed fortress on a planet that will one day become the home of the Xindi Council, strangely enough this species was the only one to have not survived the destruction of Xindus in the future
Palman Resources normally allocated to civil programs and imperial expansion are diverted to fighting back the shadows who focused thier attention on the palmans heavily in this war, during this time the Palman government collapses.
After developing faster-than-light spacefaring capabilities based upon Prothean technology, the asari begin to explore the Jump gate network, and eventually discover the huge Citadel space station at a hub of many Jump gates.
The salarians discover the Citadel and open diplomatic relations with the asari.
The last of the known ancient Jumpgates are built, marking the apparent disappearance of the Palman's civilization as no other trace of them is found, with no new automated vessels being built and sent to other galaxies, construction halts. The Jumpgate network covers the entire Andromeda,Triangulum and Milky Way galaxies, with a Slipstream gate located in each galaxy connected to the Citadel, though the supergate goes unused.
First shadow war of the council era, the salarians and asari survive the event and become stronger galactic powers, due to reverse engineering technology from past fallen races.
A group of Vulcans who do not follow Surak's teachings of logic leave their homeworld in a wave of emigration. They will finally settle on the planets Romulus and Remus, coming to be known as the Romulans and Remans.
The Jem'Hadar begin serving as the Dominion's front line of defense.
The Vidiian Sodality in the Delta Quadrant is ravaged by a deadly viral disease called the Phage. The Vidiians survive only by harvesting organs from non-Vidiians to replace their own tissues
Kahless the Unforgettable unites the Klingon people after his defeat of the tyrant Molor and the Fek'Ihri. Kahless establishes a strict warrior code that is passed down through Klingon culture to the present day.