Synthesis and Characterization of some new 2,5-disubstituted- 1,3,4-oxadiazole derivatives Containing Antipyrine moiety.

Mohammad Amin Mohammad Rashid and Sewara Jalal MohammedMohammed

Faculty of Science and Science Education, School of Science, Department of Chemistry, University of Sulaimani, Kurdistan region, Iraq

DOI: https://doi.org/10.17656/jzs.10501

Abstract

Some new 2,5-disubstituted-1,3,4-oxadiazolels of type (E)-4-((1-(5-(substitutedphenyl)

1,3,4-oxadiazol-2-yl)pro-1-en-2-yl)amino)-1,5-dimethyl-2-phenyl-1H-pyrazol-3(2H)-

one were synthesized in (60-81%) yield under solvent free conditions using grinding

technique through the reaction of hydrazide intermediate with benzaldehyde or different

substituted benzaldehydes in the presence of catalytic amounts of iodine molecular as a

single step. The structures of all the synthesized compounds were confirmed on the basis

of their physical properties, IR, 1H-NMR and Mass spectral data.

Key words:

4-Aminoantipyrine

Ethyl acetoacetate

Enaminone

Hydrazide

Oxadiazole derivatives

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