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Hawnaz Othman Najmalddin1, Aso Ahmed Taher1, and Shad Arif Mohammed1
1College of Science, University of Sulaimani.
DOI: https://doi.org/10.17656/jzs.10433
Abstract
Human endogenous retroviral element S-family (HERV-S) has been present within
the human genome as well as various closely related primates. The expression
pattern, copy number, chromosomal locations of the proviral element have been
extensively studied. Here, we analyse the pol fragment of the HERV-S in human
tissues, cancer cell lines and in seven other related primates. Phylogenetic analysis of
the HERV-S pol gene suggests division of the family into two groups among the
tested species that have arisen throughout the primate evolution by gene duplication
as well as other genetic alterations. Also, the tree analysis of human tissues and
cancer cells suggest that expression of the chromosome X pol fragment is identical to
expression of the pol fragment in cancerous cells more than its relation to the pol
sequence on other human chromosomes. To sum up, our data provide a clarification
about the dynamic evolutionary characteristics as well as phylogenetic relationships
of HERV-S family pol gene in primates.
Key Words: HERV-S, Endogenous, Phylogeny, Evolution, Primate, Cancer cell line
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