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Salam Kamal Seedo1 , Jian Salam Hassan Ali2
1 Department of Animal Hygiene, College of Veterinary Medicine, University of Duhok, Kurdistan Region, Iraq.
2 Department of Pathology and Microbiology, College of Veterinary Medicine, University of Duhok, Kurdistan Region, Iraq.
Original: 20 May 2016, Revised: 15 August 2016, Accepted: 16 October 2016, Published online: 20 March 2017
DOI: https://doi.org/10.17656/jzs.10583
Abstract
This study was carried out to investigate the effect of chamomile flower aqueous extract on different biochemical parameters in pentylenetetrazole (PTZ) induced-convulsive chicks. Parameters included were serum total antioxidant capacity (T-AOC), serum and brain gamma-aminobutyric acid (GABA), serum cholinesterase enzyme activity (ChE), electrolytes (Na+,K+, and Cl-), total calcium (Ca2+), serum glucose and total protein concentration.
The dried flowers parts of chamomile (Matricaria chamomilla L.) were subjected to aqueous extraction and given at (200, 400 and 600mg/kg orally), for its anticonvulsant effects and the effect was compared with the standard anticonvulsant drug sodium valproate (200mg/kg). A dose of 200mg/kg showed full protection against PTZ convulsions, whereas doses of 400 and 600 mg/kg reduced the latency and onset of convulsion. The results suggest that the aqueous extract of chamomile flower may produce anticonvulsant effects via biochemical changes including significant increases in serum T-AOC, serum GABA, serum ChE activity and Na+, and a significant reduction in K+ and serum glucose concentration have been observed.
Key Words:
Matricaria chamomilla L.
PTZ
T-AOC
GABA
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