Synthesis and Characterization of some new 2,5-disubstituted-1,3,4-oxadiazole derivatives Containing Antipyrine moiety

Mohammad Amin Mohammad Rashid*& Sewara Jalal Mohammed*

Faculty of Science and Science Education, School of Science, Department of Chemistry, University of Sulaimani, Kurdistan region, Iraq

*Email: 46mohrashid@web.de

Original: 12.07.2015; Revised: 08.09.2015; Accepted: 12.11.2015; Published online: 20.06.2016

DOI Link: 

ABSTRACT

Some new 2,5-disubstituted-1,3,4-oxadiazolels of type (E)-4-((1-(5-(substitutedphenyl) 1,3,4-oxadiazol-2-yl)pro-1-en-2-yl)amino)-1,5-dimethyl-2-phenyl-1H-pyrazol-3(2H)-one were synthesized in (60-81%) yield under solvent free conditions using grinding technique through the reaction of hydrazide intermediate with benzaldehyde or different substituted benzaldehydes in the presence of catalytic amounts of iodine molecular as a single step. The structures of all the synthesized compounds were confirmed on the basis of their physical properties, IR, 1H-NMR and Mass spectral data.

KEYWORDS

4-Aminoantipyrine,

Ethyl acetoacetate 

Enaminone 

Hydrazide 

Oxadiazole derivatives

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