Tick Bites & Lyme

Vol. 279 No. 3, January 21, 1998


Online Features

Original Contribution

Tick Bites and Lyme Disease in an Endemic Setting

Problematic Use of Serologic Testing and Prophylactic Antibiotic Therapy

Alan D. Fix, MD, MS; G. Thomas Strickland, MD, PhD; John Grant, MD, MPH

JAMA. 1998;279:206-210.


Context.— The use of serologic testing to diagnose Lyme disease (LD) is a source of controversy. Expert recommendationsalso discourage the routine use of antibiotic therapy for prophylaxis of LD following tick bites, but the extent to which physicians in endemic areas have adopted these recommendations is not known.

Objective.— To assess the pattern of use of serologic testing and antibiotic therapy for tick bites and LD and associatedcharges for management in an endemic area.

Design.— Active surveillance of patient-physician encounters for tick bites and LD.

Setting.— Primary care practices on the Eastern Shore of Maryland.

Patients.— Consecutive sample of 232 patients with tick bites, LD (defined by physician diagnosis in medical record), and suspected LD (physician notation of possible, but not definite LD) seen in 1995.

Main Outcome Measures.— Serologic testing for LD, test results, antibiotic therapy, and direct costs of management.

Results.— Surveillance identified 142 patients (61.2%) with diagnoses of tick bites, 40 patients (17.2%) with LD, and 50 patients (21.6%) with suspected LD. Of the 142 patients seen for tick bites, 95 (67%) underwent serologic testing for LD.

Of these, 93 patients had initial negative or equivocal results; 24 (26%) of the 93 had convalescent testing, with 1 seroconversion.

Seventy-eight patients (55%) with a diagnosis of tick bite received antibiotic therapy. No patients with tick bite developed clinical LD.

Serologic testing for LD was performed for 36 patients (90%) with a diagnosis of LD and 46 patients (92%) with suspected LD. In most cases, antibiotics were prescribed before serologic test results became available.

Convalescent testing was not performed for 37 (86%) of the 43 patients with suspected LD who had initial negative or equivocal results. Of these 37 patients, 25 (68%) did not receive antibiotic therapy.

Direct charges for treatment of these 232 patients totaled $47595, one third of which was attributable to serologic testing.

A total of 32% of direct charges were for patients with tick bites, 48% were for patients with LD, and 20% were for patients with suspected LD.

Conclusions.— In this setting, most patients consulting physicians for tick bites received prophylactic antibiotic therapy of unproven efficacy and underwent unnecessary, costly serologic testing. Despite almost universal use in this study, serologictesting for LD did not appear to influence treatment of patients diagnosed as having LD.

Last Updated- April 2019

Lucy Barnes