David H. Walker

Co-Chair of 2019 TBDWG

And they all lived together in a little crooked house.

David Walker, currently appointed as co-chair of the federal Tick Borne Disease Working Group (2019), already has a bad reputation in the Lyme community.

The documentation below will make you question why he was chosen as the Co-Chair of the federal Tick Borne Disease Working Group, especially considering his long history with and connections to Edward McSweegan, the IDSA guidlines authors and their close-knit circle of biased intolerables.

IOM Meeting

October 11 & 12, 2010

David Walker was on the original planning committee for the IOM's Lyme Disease & Other Diseases: State of the Science. He also chaired a panel with Peter Krause (IDSA guideline author) and was on the Summation Panel.

This IOM group played dirty from the beginning and in a first of its kind move, most of the Lyme organizations, groups and patient advocates boycotted the meeting in protest.

Those selected to speak at the IOM meeting included David Walker and his co-authors and friends- Gary Wormser, Peter Krause, Steven Dumler, Janis Weis, Linda Bockenstedt, Paul Meade, John Aucott and Susan O'Connell. (IDSA guideline authors are in bold print. See IOM agenda and schedule below.)

SOURCE http://www.nationalacademies.org/hmd/Activities/Disease/TickBorne.aspx

David Walker- An NIH "Grant Sponge"

Sucking Up The Dollars For Decades

David Walker- Regular NIH Rickettsia Related Grants

Total $34,574,832

David Walker- Additional NIH Grants

More than $102 million dollars

Out of 124 regular NIH grants to David Walker (not all inclusive)

33 grants were for studying rickettsia (spotted fever) antigens (1985- 2013) [YEAR AFTER YEAR SOAKING UP MILLIONS IN FUNDING AND STILL NO ACCURATE TESTS, VACCINES OR SUCCESSFUL TREATMENTS WERE DEVELOPED]

BTW- McStupid (Edward McSweegan, NIH) and Phillip Baker (Director of fake grass roots American Lyme Disease Foundation (ALDF), previously at NIH) both worked with vector borne related grants at NIH when David Walker was getting his boat load of tax-payer's money from NIH to study rickettsia organisms.

To Note- McStupid claims he was a "Program Officer" at his NIH job, from Sep 1991 - Dec 2013. He stated he was responsible to- "Manage a portfolio of infectious disease and epidemiology training grants." Source

DAVID WALKER

24 grants for studying rickettsia and other organisms (1993- 2018)

19 grants for Ehrlichia (1991- 2012)

15 grants for biowarfare (Rickettsia included in some)

10 grants for typhus, leptospirosis and/or viruses

20 grants misc.- develop plans, admin costs, training costs, etc.

At Least SIX of the NIH Grants

To David Walker Came From

Phillip "Cry Baby" Baker

Several shown here.

At Least TWENTY of the NIH Grants

To David Walker Came From

A 2019 TBDWG Member

Samuel Perdue

[From TBDWG site- "Dr. Perdue is Chief of the Basic Sciences Section within the Bacteriology and Mycology Branch, NIAID, NIH. This section comprises program officials who oversee NIAID extramural research funding in Lyme disease, other bacterial zoonoses, hospital infections, antibacterial resistance, medical mycology and biodefense.

Dr. Perdue also serves as NIAID’s program officer for rickettsial and related diseases, where he has primary responsibility for the institute’s grants on Rickettsia, Anaplasma, Ehrlichia, Bartonella and Coxiella species, among others." Source

See screen shot below and the 20 grants posted here.

PATENTS

1st David Walker grant in 1985 and most the recent grant in 2013 listed:

Patent- NIH #6806065- Rickettsia felis outer membrane protein.

His most recent grant lists 13 additional patents for rickettsia and other organisms. (See list below.)

David Walker's Grants

(Patents Are Appreciated By The Federal Government)

EXAMPLE- Parent Project Number: 2U54AI057156-06 Sub-Project ID: 6297

Contact PI / Project Leader: WALKER, DAVID H

Title: ADMINISTRATIVE CORE

Awardee Organization: UNIVERSITY OF TEXAS MED BR GALVESTON

The Western Regional Center of Excellence for Biodefense and Emerging Infectious Diseases Research (WRCE) is located in DHHS Region VI, including Texas, New Mexico, Oklahoma, Arkansas, and Louisiana. Dr. David H. Walker is the PI and director for the WRCE.

In the assessment of the national RCE Program, several individual Center measurements were provided. They revealed that the WRCE ranked first in the number of organisms studied, total number of projects, number of Pis, additional non- RCE funding stemming from WRCE research, and number of patent applications as compared to the other individual Centers [1]. Our publication rate is also the one of the highest of the Centers.

Source- https://projectreporter.nih.gov/project_info_description.cfm?aid=7676462&map=y

Partial List of Patents

David Walker

Patent Number Patent Title Patent Owner Primary Agency

7803363

Attenuated Francisella bacteria

UNIVERSITY OF TEXAS SAN ANTONIO

NIH

8426188

Attenuated recombinant alphaviruses incapable of replicating in mosquitoes and uses thereof

UNIVERSITY OF TEXAS MED BR GALVESTON

NIH

8343506

Chimeric chikungunya virus and uses thereof

UNIVERSITY OF TEXAS MED BR GALVESTON

NIH

8748591

Chimeric sindbis-western equine encephalitis virus and uses thereof

UNIVERSITY OF TEXAS MED BR GALVESTON

NIH

9267947

Compositions and methods for preventing or treating Burkholderia infection

UNIVERSITY OF TEXAS MED BR GALVESTON

NIH

9248176

Controlled release vaccines and methods for treating Brucella diseases and disorders

TEXAS A&M UNIVERSITY

NIH

8889743

Inhibition of filovirus entry into cells and uses thereof

UNIVERSITY OF TEXAS MED BR GALVESTON

NIH

8883729

Nanolipoprotein particles and related compositions, methods and systems

UNIVERSITY OF TEXAS MED BR GALVESTON

NIH

8252574

Pseudoinfectious flavivirus and uses thereof

UNIVERSITY OF TEXAS MED BR GALVESTON

NIH

9144605

Recombinant rift valley fever virus encoding a dominant-negative inhibitor of DSRNA-dependent protein kinase in the NSS region

UNIVERSITY OF TEXAS MED BR GALVESTON

NIH

8084248

Reverse genetic system for rift valley fever virus and uses thereof

UNIVERSITY OF TEXAS MED BR GALVESTON

NIH

8030447

Substrate peptide sequences for plague plasminogen activator and uses thereof

UNIVERSITY OF TEXAS MED BR GALVESTON

NIH

8394620

Two-component genome flavivirus and uses thereof

UNIVERSITY OF TEXAS MED BR GALVESTON

NIH

Source

http://patft1.uspto.gov//netacgi/nph-Parser?Sect1=PTO1&Sect2=HITOFF&d=PALL&p=1&u=%2Fnetahtml%2FPTO%2Fsrchnum.htm&r=1&f=G&l=50&s1=6806065.PN.&OS=PN/6806065&RS=PN/6806065

Edward McSweegen Article

Another Biased, One-Sided Panel

23 September 2010

Pity the IOM staff

From some cranky Lyme activists:

Congress asked for a state-of-the-science evaluation of Lyme disease. What the Institute of Medicine is offering, however, is a one-sided, biased presentation of the Infectious Diseases Society of America's point of view. Because the IOM refuses to allow speakers of comparable scientific weight to counter the IDSA viewpoint, three major Lyme patient groups have withdrawn their participation.

This is quickly becoming redundant. Lyme activists can bitch to each other all they want, but they have to explain to everyone else how a workshop that includes Lyme activists (e.g. Carl Brenner, Pam Weintraub), “Lyme Literate” docs (e.g., Brian Fallon, Sam Donta), and non-IDSA scientists (e.g., Janis Weis, Howard Ginsberg, Dave Walker) can be “a one-sided biased presentation.” ...

Source- https://sites.google.com/site/edwardmcsweegan/iom-member/iom-quotes

Thirteen David Walker Publications With Coauthors From IDSA Lyme Guidelines & CDC

And they all lived together in a little crooked house.

Barbour (guidelines), Dumler (Hopkins & guidelines), Dennis (CDC & guildeines) and McSweegan (IDSA Mouthpiece).

Emerging bacterial zoonotic and vector-borne diseases. Ecological and epidemiological factors.

Walker DH, Barbour AG, Oliver JH, Lane RS, Dumler JS, Dennis DT, Persing DH, Azad AF, McSweegan E.

JAMA. 1996 Feb 14;275(6):463-9. Review.

PMID: 8627968

~~

The role of CD8 T lymphocytes in rickettsial infections.

Walker DH, Dumler JS.

Semin Immunopathol. 2015 May;37(3):289-99. doi: 10.1007/s00281-015-0480-x. Epub 2015 Apr 1. Review.

PMID: 25823954

~~

Emerging and re-emerging tick-transmitted rickettsial and ehrlichial infections.

Walker DH, Paddock CD, Dumler JS.

Med Clin North Am. 2008 Nov;92(6):1345-61, x. doi: 10.1016/j.mcna.2008.06.002. Review.

PMID: 19061755

~~

Rocky Mountain spotted fever--changing ecology and persisting virulence.

Dumler JS, Walker DH.

N Engl J Med. 2005 Aug 11;353(6):551-3. No abstract available.

PMID: 16093463

~~

Fatal spotted fever rickettsiosis, Minas Gerais, Brazil.

Galvâo MA, Dumler JS, Mafra CL, Calic SB, Chamone CB, Cesarino Filho G, Olano JP, Walker DH.

Emerg Infect Dis. 2003 Nov;9(11):1402-5.

PMID: 14718082

~~

The incidence of ehrlichial and rickettsial infection in patients with unexplained fever and recent history of tick bite in central North Carolina.

Carpenter CF, Gandhi TK, Kong LK, Corey GR, Chen SM, Walker DH, Dumler JS, Breitschwerdt E, Hegarty B, Sexton DJ.

J Infect Dis. 1999 Sep;180(3):900-3.

~~

Dual infection with Ehrlichia chaffeensis and a spotted fever group rickettsia: a case report.

Sexton DJ, Corey GR, Carpenter C, Kong LQ, Gandhi T, Breitschwerdt E, Hegarty B, Chen SM, Feng HM, Yu XJ, Olano J, Walker DH, Dumler SJ.

Emerg Infect Dis. 1998 Apr-Jun;4(2):311-6.

PMID: 9621205

~~

Emerging and reemerging rickettsial diseases.

Walker DH, Dumler JS.

N Engl J Med. 1994 Dec 15;331(24):1651-2. No abstract available.

PMID: 7969347

~~

Diagnostic tests for Rocky Mountain spotted fever and other rickettsial diseases.

Dumler JS, Walker DH.

Dermatol Clin. 1994 Jan;12(1):25-36. Review.

PMID: 8143383

~~

Brazilian spotted fever in Espirito Santo, Brazil: description of a focus of infection in a new endemic region.

Sexton DJ, Muniz M, Corey GR, Breitschwerdt EB, Hegarty BC, Dumler S, Walker DH, Pecanha PM, Dietze R.

Am J Trop Med Hyg. 1993 Aug;49(2):222-6.

PMID: 8357085

~~

Rocky Mountain spotted fever complicated by gangrene: report of six cases and review.

Kirkland KB, Marcom PK, Sexton DJ, Dumler JS, Walker DH.

Clin Infect Dis. 1993 May;16(5):629-34. Review.

PMID: 8507753

~~

Human ehrlichiosis: hematopathology and immunohistologic detection of Ehrlichia chaffeensis.

Dumler JS, Dawson JE, Walker DH.

Hum Pathol. 1993 Apr;24(4):391-6.

PMID: 8491479

~~

Clinical and laboratory features of murine typhus in south Texas, 1980 through 1987.

Dumler JS, Taylor JP, Walker DH.

JAMA. 1991 Sep 11;266(10):1365-70.

PMID: 1880866

Conflicts of Interest

David Walker doesn't seem very fond of listing his conflicts of interest for his publications. With over a dozen patents and ties to the IDSA authors you'd think that would be something important to share.

Rickettsia australis Activates Inflammasome in Human and Murine Macrophages

2016- Competing Interests: The authors have declared that no competing interests exist.

https://journals.plos.org/plosone/article?id=10.1371/journal.pone.0157231

WHERE'S THE BEEF?

David Walker, in spite of all that money, was unable to develop a reliable test, improved treatment method or a rickettsia vaccine. BUT, he knew back in 1996 that it wasn't possible- over twenty years ago- so why continue letting him ride on the grant gravy train? His connection with Samuel Perdue (also on the TBDWG 2019) makes them both suspect.

QUOTE- "Vaccines against spotted fever and typhus group rickettsiae have been developed empirically by propagation of rickettsiae in ticks, lice, embryonated hen eggs, and cell culture. Vaccines containing killed organisms have provided incomplete protection.

A live attenuated vaccine against epidemic typhus has proved successful, but is accompanied by a substantial incidence of side effects, including a mild form of typhus fever in some persons."

QUOTE- "Scrub typhus can be treated with doxycycline, tetracycline, or chloramphenicol. Chigger repellents may prevent exposure. Prophylaxis with weekly doses of doxycycline during and for 6 weeks after exposure protects against scrub typhus. Attempts to develop a safe, effective vaccine have failed."

Medical Microbiology. 4th edition. 1996.

Chapter 38 Rickettsiae. David H. Walker.

Galveston (TX): University of Texas Medical Branch at Galveston; 1996.

Source https://www.ncbi.nlm.nih.gov/books/NBK7624/

Using Federal Grants- Millions of Dollars

Then Publishing Their Study Results

In Journals Where He (David Walker) Is An Editor

And if he isn't an editor, his IDSA/CDC

Guideline authors and buddies are.

https://sites.google.com/site/lymelegislation/2019-working-group-federal/david-walker-editing-journals-he-published-in-federal-grants