E621

Jenisa Phetlek, Yanisa Nucharoen

Advisor Pailin Saelim

Abstract

Metal particles that use in artificial metal joint replacement or metal bone splint for broken bone have adverse effects on human cells and tissues. (Valerio S. et al., 2013)This research studied about mechanical properties of artificial bones produced by Hydroxyapatite, Polymethymethacrylate and Chitosan these substance have researches support that not do harm with human tissue and suitable for use in bone engineering. Producing artificial bone by admix Hydroxyapatite and Chitosan together and use Polymethylmethacrylate as merger between Hydroxyapatite and Chitosan, Varying only ratio of Hydroxyapatite : Chitosan while the ratio of Polymethylmethacrylate in the artificial bone is invariable. The different ratios of Polymethylmethacrylate : Hydroxyapatite : Chitosan include 9:1:0, 9:0.667:0.333, 9:0.5:0.5, 9:0.333:0.667 and 9:0:1 (g). Each products will be compared the mechanical properties by Universal testing machine then analyze the chemical properties by Fourier-transform infrared spectroscopy (FTIR). From experiment the result of compression strength that give most young's modulus is the artificial bone that product by using ratio of substance in 9:0:1. Most young's modulus that means product in this ratio have most stiffness compare with other ratio and FTIR graph showed that the sample in various ratio have slightly change when compare each function group with FTIR of function group in pure PMMA, pure Hydroxyapatite and pure Chitosan that means peaks of function group in the graph of artificial bone be overlapped predict that some substance have chemical reaction together.