Publications

[Proc] 林聖也、福島諒大、高松利寛、梅澤雅和、曽我公平、横田秀夫、竹村裕「リアルタイムに対象識別を可能とする近赤外マルチスペクトラルイメージング腹腔鏡システムの開発」生体医工学（日本生体医工学会）、62: 474-475（2024年10月）https://doi.org/10.11239/jsmbe.Annual62.474 [J-STAGE]

[Review] Umezawa M, Soga K: Navigating the invisible realm: Near-infrared fluorescence imaging of nanoparticle behavior in biological tissues. Bioimages, 32: 1-11 (Aug 2024) https://doi.org/10.11169/bioimages.32.1 [J-STAGE]

Umezawa M, Haraguchi H, Sugawara G, Sato K, Kurahashi H, Oda T, Okubo K, Soga K: Temperature imaging inside fluid devices using a ratiometric near infrared (NIR-II/III) fluorescent Y2O3: Nd3+, Yb3+, Er3+ nanothermometer. Analytical Sciences, 40(7): 1323-1330 (July 2024) https://doi.org/10.1007/s44211-024-00564-0 [PubMed] [Open Access] (Awardrd as Hot Article 2024)

Kurahashi H, Umezawa M, Okubo K, Soga K: Pixel-screening in lifetime-based temperature mapping using β-NaYF4: Nd3+,Yb3+ by time-gated near-infrared fluorescence imaging on deep tissue in live mice. ACS Applied Bio Materials, 7(6): 3821-3827 (June 2024) https://doi.org/10.1021/acsabm.4c00201 [PubMed] [Open Access @ACS]

Takamatsu T, Fukushima R, Sato K, Umezawa M, Yokota H, Soga K, Hernández-Guedes A, Callicó G, Takemura H: Development of a visible and over 1000 nm hyperspectral imaging rigid-scope system using supercontinuum light and an acousto-optic tunable filter. Optics Express, 32(9): 16090-16102 (Apr 2024) https://doi.org/10.1364/OE.515747 [PubMed] [Open Access] ➡ プレスリリース「可視～近赤外の広範囲でハイパースペクトルイメージングが可能な硬性内視鏡システムを開発」

Fukushima R, Takamatsu T, Sato K, Okubo K, Umezawa M, Takeshita N, Hasegawa H, Yokota H, Soga K, Takemura H: Non-invasive imaging of exposed nerves in vivo with near-infrared hyperspectral laparoscopic devices. Proc. SPIE, 12928 (Medical Imaging 2024: Image-Guided Procedures, Robotic Interventions, and Modeling): 129281X (Mar 2024) https://doi.org/10.1117/12.3006474

Fukushima R, Takamatsu T, Sato K, Hernández-Guedes A, Callicó G, Okubo K, Umezawa M, Yokota H, Soga K, Takemura H: Detection of exposed nerves in two individuals in vivo and unexposed nerves ex vivo with near-infrared hyperspectral laparoscope. 2024 IEEE/SICE International Symposium on System Integration (SII), 19-24 (Jan 2024) https://doi.org/10.1109/SII58957.2024.10417671

Doan TKD, Umezawa M, Okubo K, Kamimura M, Soga K: Enhancing near-infrared fluorescence intensity and stability of PLGA-b-PEG micelles by introducing Gd-DOTA at the core boundary. Journal of Biomedical Materials Research: Part B - Applied Biomaterials, 112(1): e35327 (Jan 2024) https://doi.org/10.1002/jbm.b.35327 [PubMed]

Mori A, Umezawa M, Okubo K, Kamiya T, Kamimura M, Ohtani N, Soga K: Visualization of hydrocarbon chain length and degree of saturation of fatty acids in mouse livers by combining near-infrared hyperspectral imaging and machine learning. Scientific Reports, 13: 20555 (Nov 2023) https://doi.org/10.1038/s41598-023-47565-z [PubMed][Open Access] ➡プレスリリース「生体組織中の脂肪酸分布の特徴を無標識で可視化する手法を開発」"New Study Unveils Machine Learning-Aided Non-Invasive Imaging for Rapid Liver Fat Visualization"

[Review] 梅澤雅和「“第2の生体の窓” 近赤外蛍光生体イメージングのためのナノ材料設計」バイオマテリアル（日本バイオマテリアル学会）、41(4): 290-295 (2023年10月)

Mitsui T, Mori A, Takamatsu T, Kadota T, Sato K, Fukushima R, Okubo K, Umezawa M, Takemura H, Yokota H, Kuwata T, Kinoshita T, Ikematsu H, Yano T, Maeda S, Soga K: Evaluating the identification of the extent of gastric cancer by over-1000 nm near-infrared hyperspectral imaging using surgical specimens. Journal of Biomedical Optics, 28(8): 086001 (Aug 2023) https://doi.org/10.1117/1.JBO.28.8.086001 [PubMed] [Open Access]

Doan TKD, Umezawa M, Ikeda K, Ohnuki K, Akatsuka M, Okubo K, Kamimura M, Yamaguchi M, Fujii H, Soga K: The influence of carboxyl group ratios on the design of breast cancer targeting bimodal MR/NIR-II imaging probe from PLGA@Gd-DOTA@PEG micelles conjugating Herceptin. ACS Applied Bio Materials, 6(7): 2644-2650 (June 2023) https://doi.org/10.1021/acsabm.3c00260 [PubMed]

[Review] Umezawa M, Ueya Y, Ichihashi K, Dung DTK, Soga K: Controlling molecular dye encapsulation in the hydrophobic core of core-shell nanoparticles for in vivo imaging. Biomedical Materials and Devices, 1: 605-617 (Apr 2023) https://doi.org/10.1007/s44174-023-00073-0 [PubMed] [Open Access]

Fukushima R, Takamatsu T, Mori A, Sato K, Okubo K, Umezawa M, Takeshita N, Hasegawa H, Yokota H, Soga K, Takemura H: Hyperspectral imaging and detection mapping of in vivo biological tissues applying near-infrared laparoscope. Proc. SPIE, 12466 (Medical Imaging 2023: Image-Guided Procedures, Robotic Interventions, and Modeling): 124662K (Apr 2023) https://doi.org/10.1117/12.2653684

Umezawa M, Kurahashi H, Nigoghosian K, Okubo K, Soga K: Designing Er3+/Ho3+-doped near-infrared (NIR-II) fluorescent ceramic particles for avoiding optical absorption by water. Journal of Photopolymer Science and Technology, 35(1): 9-16 (2022) https://doi.org/10.2494/photopolymer.35.9 [Open Access @J-STAGE]

Doan TKD, Umezawa M, Okubo K, Kamimura M, Yamaguchi M, Fujii H, Soga K: The effect of Gd-DOTA locations within PLGA-b-PEG micelles encapsulated IR-1061 on bimodal over-1000 nm near-infrared fluorescence and magnetic resonance imaging. Biomaterial Science, 10: 6244-6257 (2022) https://doi.org/10.1039/D2BM01213H [PubMed] [Open Access @RSC]

Umezawa M, Miyata K, Okubo K, Soga K: Three dimensional lifetime-multiplex tomography based on time-gated capturing of near-infrared fluorescence images. Applied Sciences, 12: 7721 (2022) https://doi.org/10.3390/app12157721

Ueya Y, Umezawa M, Kobayashi Y, Ichihashi K, Kobayashi H, Matsuda T, Takamoto E, Kamimura M, Soga K: Effects of hydrophilic/hydrophobic blocks ratio of PEG-b-PLGA on emission intensity and stability of over-1000 nm near-infrared fluorescence dye-loaded polymeric micellar nanoparticles. Analytical Sciences, 38: 199-205 (2022) https://doi.org/10.2116/analsci.21P283 [PubMed] (Awardrd as Hot Article 2022)

Umezawa M, Kobayashi H, Ichihashi K, Sekiyama S, Okubo K, Kamimura M, Soga K: Heat treatment effects for controlling dye molecular states in hydrophobic core of over-1000nm near-infrared (NIR-II) fluorescent micellar nanoparticles. ACS Omega, 7(7): 5817-5824 (2022) http://doi.org/10.1021/acsomega.1c05771 [PubMed] [Open Access @ACS]

Doan TKD, Umezawa M, Ohnuki K, Nigoghossian K, Okubo K, Kamimura M, Yamaguchi M, Fujii H, Soga K: The influence of Gd-DOTA conjugating ratios to PLGA-PEG micelles encapsulated IR-1061 on bimodal over-1000 nm near-infrared fluorescence and magnetic resonance imaging. Biomaterial Science, 10: 1217-1230 (2022) https://doi.org/10.1039/D1BM01574E [PubMed] [Open Access @RSC]

Doan TKD, Umezawa M, Kobayashi H, Oshima A, Ikeda K, Okubo K, Kamimura M, Soga K: Influence of physiological media on over-1000 nm NIR fluorescent DSPE-PEG micelles for bio-imaging. Chemistry Letters, 51(2): 208-211 (2022) https://doi.org/10.1246/cl.210700 [Open Access]

Takematsu M, Umezawa M, Sera T, Kitagawa Y, Kurahashi H, Yamada S, Okubo K, Kamimura M, Yokota H, Soga K: Influence of the difference in refractive index on the interface of an object and the surrounding in near-infrared fluorescence tomography. Applied Optics, 61(2): 638-644 (2022) https://doi.org/10.1364/AO.445357 [PubMed]

Ichihashi K, Umezawa M, Ueya Y, Okubo K, Takamoto E, Matsuda T, Kamimura M, Soga K: Effect of the enantiomeric structure of hydrophobic polymers on the encapsulation properties of a second near infrared (NIR-II) fluorescent dye for in vivo deep imaging. RSC Advances, 12(3): 1310-1318 (2022) https://doi.org/10.1039/d1ra08330a [PubMed] [Open Access @RSC]

Yahata A, Takemura H, Iwanami R, Umezawa M, Okubo K, Soga K, Takamatsu T, Mitsui T, Kadota T, Kuwata T, Ikematsu H, Yokota H: Gastric cancer detection by two-step learning in near-infrared hyperspectral imaging. Journal of Information and Communication Engineering (JICE), 8(2): 467-473 (2021)

Yahata A, Takemura H, Takamatsu T, Yokota H, Iwanami R, Umezawa M, Okubo K, Soga K, Mitsui T, Kadota T, Kuwata T, Ikematsu H: "Wavelength selection of near-infrared hyperspectral imaging for gastric cancer detection." 2021 6th International Conference on Intelligent Informatics and Biomedical Sciences (ICIIBMS), 219-223 (2021) https://doi.org/10.1109/ICIIBMS52876.2021.9651625

[Review] Okubo K, Umezawa M, Soga K: Near infrared fluorescent nanostructure design for organic/inorganic hybrid system. Biomedicines, 9(11): 1583 (2021)  https://doi.org/10.3390/biomedicines9111583 [PubMed] [Open Access]
> Design basics of near infrared fluorescent nanostructure
> Dye-loaded nanostructure for NIR fluorescence
> Organic/inorganic hybrid nanostructure for NIR fluorescence

Fang S, Umezawa M, Okubo K, Soga K: Polymer-based near-infrared afterglow fluorescent complex of dye and rare-earth-doped ceramics. Journal of Photopolymer Science and Technology, 34(1): 7-10 (2021) https://doi.org/10.2494/photopolymer.34.7 [Open Access @J-STAGE]

Ueya Y, Umezawa M, Kobayashi Y, Kobayashi H, Ichihashi K, Matsuda T, Takamoto E, Kamimura M, Soga K: Design of over-1000 nm near-infrared fluorescent polymeric micellar nanoparticles by matching the solubility parameter of the core polymer and dye. ACS Nanoscience Au, 1: 61-68 (2021) https://doi.org/10.1021/acsnanoscienceau.1c00010 [Open Access @ACS]

[Review] Okubo K, Umezawa M, Soga K: Concept and application of thermal phenomena at 4f electrons of trivalent lanthanide ions in organic/inorganic hybrid nanostructure. ECS Journal of Solid State Science and Technology, 10: 096006 (2021) https://doi.org/10.1149/2162-8777/ac2327 [Open Access @IOP]
> Thermal phenomena at 4f electrons of trivalent lanthanide ions
> Interpretation from phonon in crystal to vibration in molecular system
> Lanthanide-doped nanocrystals in organic system
> Applications of thermal absorption
> Applications of biothermometry

Nomura K, Umezawa M, Tezuka K, Tasaki T, Okubo K, Soga K: Effect of polarization of surrounding organic molecules on upconversion emission of β-NaYF4 co-doped with Er3+ and Yb3+. Journal of Luminescence, 239: 118394 (2021) https://doi.org/10.1016/j.jlumin.2021.118394 

[Notes] 手塚景子、梅澤雅和、劉得懿、野村洸希、大久保喬平、邱信程、上村真生、曽我公平「アップコンバージョン発光ナノ粒子と疎水化ローズベンガルを用いた近赤外光線力学療法のための新奇ハイブリッドナノ構造」バイオイメージング（日本バイオイメージング学会）、30(1): 1 (2021) [日本語} 

Ueya Y, Umezawa M, Takamoto E, Yoshida M, Kobayashi H, Kamimura M, Soga K: Designing highly emissive over-1000-nm near-infrared fluorescent dye-loaded polystyrene-based nanoparticles for in vivo deep imaging. RSC Advances, 11: 18930-18937 (2021) https://doi.org/10.1039/D1RA01040A [PubMed] [Open Access @RSC]

Tezuka K, Umezawa M, Liu T-I, Nomura K, Okubo K, Chiu H-C, Kamimura M, Soga K: Upconversion luminescent nanostructure with ultrasmall ceramic nanoparticles coupled with rose bengal for NIR-induced photodynamic therapy. ACS Applied Bio Materials, 4(5): 4462-4469 (2021) https://doi.org/10.1021/acsabm.1c00213 [PubMed] [Open Access @ACS]

Takamatsu T, Kitagawa Y, Akimoto K, Iwanami R, Endo Y, Takashima K, Okubo K, Umezawa M, Kuwata T, Sato D, Kadota T, Mitsui T, Ikematsu H, Yokota H, Soga K, Takemura H: Over 1000 nm near-infrared multispectral imaging system for laparoscopic in vivo imaging. Sensors, 21(8): 2649 (2021) https://doi.org/10.3390/s21082649 [PubMed] [Open Access]

Okubo K, Takeda R, Murayama S, Umezawa M, Kamimura M, Osada K, Aoki I, Soga K: Size-controlled bimodal in vivo nanoprobes as near-infrared phosphors and positive contrast agents for magnetic resonance imaging. Science and Technology of Advanced Materials, 21(1): 160-172 (2021) https://doi.org/10.1080/14686996.2021.1887712 [PubMed] [Open Access @Taylor] ➡ プレスリリース「セラミックスナノ粒子が拓く2モード生体イメージング」(NIMS)

Umezawa M, Haruki M, Yoshida M, Kamimura M, Soga K: Effects of processing pH on emission intensity of over-1000 nm near-infrared fluorescence of dye-loaded polymer micelle with polystyrene core. Analytical Sciences, 37: 485-489 (2021) https://doi.org/10.2116/analsci.20scp09 [PubMed] [Open Access @J-STAGE] (Awarded as Most Cited Paper Award 2022)

Okubo K, Kitagawa Y, Hosokawa N, Umezawa M, Kamimura M, Kamiya T, Ohtani N, Soga K: Visualization of quantitative lipid distribution in mouse liver through near-infrared hyperspectral imaging. Biomedical Optics Express, 12(2): 823-835 (2021) https://doi.org/10.1364/BOE.413712 [PubMed] [Open Access @OSA] ➡ プレスリリース「近赤外線ハイパースペクトルイメージングでマウス肝臓中の脂質濃度可視化に成功」➡ Technology.com (May 26, 2021), A Non-Invasive Look at Fat Distribution in the Liver (May 31, 2021 @Labroots)

[Book] Soga K, Umezawa M, Okubo K (Eds.): Transparency in Biology: Making the Invisible Visible. Springer (Singapore) (2021) https://doi.org/10.1007/978-981-15-9627-8 [Book]

[Review] Onoda A, Umezawa M: Carbon nanotubes—Potential of use for deep bioimaging. in: Soga K et al., (Eds.) "Transparency in Biology: Making the Invisible Visible", Chapter 5, pp.85-107; Published by Springer (Singapore) (2021) https://doi.org/10.1007/978-981-15-9627-8_5 [Chapter]
> Single-walled carbon nanotubes (SWCNTs) as an over 1000-nm near-infrared (OTN-NIR) fluorophore
> In vivo deep imaging and biosensing by OTN-NIR fluorescence imaging with SWCNTs
> Various physicochemical properties of CNTs
> Unique in vivo behavior of CNTs
> Unique biological effects of CNTs
> Control of biological response to CNTs by their surface modification

[Review] Umezawa M, Nigoghossian K: Nanothermometry for deep tissues by using near-infrared fluorophores. in: Soga K et al., (Eds.) "Transparency in Biology: Making the Invisible Visible", Chapter 7, pp.139-166; Published by Springer (Singapore) (2021) https://doi.org/10.1007/978-981-15-9627-8_7 [Chapter]
> Body temperature of deep tissues in biology (Mechanisms of its control / Sensitive biomolecules and receptors / Significance in clinical biology)
> Present techniques of body temperature measurement
> Contactless luminescence thermometry (LNTh) - Rare-earth-doped ceramic nanoparticles (RED-CNPs) & quantum dots for OTN-NIR LNTh

Sato D, Takamatsu T, Umezawa M, Kitagawa Y, Maeda K, Hosokawa N, Okubo K, Kamimura M, Kadota T, Akimoto T, Kinoshita T, Yano T, Kuwata T, Ikematsu H, Takemura H, Yokota H, Soga K: Distinction of surgically resected gastrointestinal stromal tumor by near-infrared hyperspectral imaging. Scientific Reports, 10: 21852 (2020) https://doi.org/10.1038/s41598-020-79021-7 [PubMed] [Open Access @NPG] ➡ プレスリリース「近赤外光を利用したハイパースペクトル画像から粘膜下腫瘍(GIST)を識別～GISTの早期発見、切除部位の最小化につながる画像識別手法の開発～」

[Review] 梅澤雅和、曽我公平「生体はどうすれば透明になるか？」ぶんせき（日本分析化学会）、2020(11): 420-425 (2020) [日本語]
> なぜ生体は透明に見えないのか
> 透明化試薬
> 生きたまま生体を透明に観察できる近赤外蛍光イメージング
> 近赤外蛍光イメージングの特長―高い時間分解能と多色性
> 多色性を活かした生体深部温度イメージング
> OTN近赤外蛍光CTによる三次元イメージング

Umezawa M, Sera T, Yokota H, Takematsu M, Morita M, Yeroslavsly G, Kamimura M, Soga K: Computed tomography for in vivo deep over-1000 nm near-infrared fluorescence imaging. Journal of Biophotonics, 13(8): e202000071 (2020) https://doi.org/10.1002/jbio.202000071 [PubMed]

Yeroslavsky G, Okubo K, Umezawa M, Nigoghossian K, Dung DTK, Miyata K, Nomura K, Kamimura M, Soga K: Energy transfer between rare earth-doped ceramic nanoparticles for gauging strain and temperature in elastic polymers. Journal of Photopolymer Science and Technology, 33(1): 129-137 (2020) https://doi.org/10.2494/photopolymer.33.129 [Open Access @J-STAGE]

[Review] Dung DKT, Umezawa M, Nigoghossian K, Yeroslavsky G, Okubo K, Kamimura M, Yamaguchi M, Fujii H, Soga K: Development of molecular imaging probe for dual NIR/MR imaging. Journal of Photopolymer Science and Technology, 33(1): 117-122 (2020) https://doi.org/10.2494/photopolymer.33.117 [Open Access @J-STAGE]

Nigoghossian K, Miyashita T, Omura A, Yeroslavsky G, Dung DTK, Okubo K, Umezawa M, Kamimura M, Soga K: Infrared to visible upconversion luminescence of trivalent erbium tetrafluoroborate complexes. Optical Materials Express, 10(7): 1749-1766 (2020) https://doi.org/10.1364/OME.395626 [Open Access @OSA]

Yeroslavsky G, Umezawa M, Okubo K, Nigoghossian K, Dung DTK, Miyata K, Kamimura M, Soga K: Stabilization of indocyanine green dye in polymeric micelles for production of a versatile theranostic platform. Biomaterials Science, 8: 2245-2254 (2020) https://doi.org/10.1039/c9bm02010a [PubMed]

[Review] 梅澤雅和、曽我公平「OTN近赤外蛍光イメージングのバイオメディカル分野への応用」画像ラボ（日本工業出版）、別冊「赤外線カメラの基本と検査・解析ソリューション」pp.23-28 (2020)

[Review] Soga K, Kamimura M, Okubo K, Umezawa M, Doan TKD, Nigghossian K: Near infrared biomedical imaging for transparency. Journal of the Imaging Society of Japan, 58(6): 602-616 (2019) https://doi.org/10.11370/isj.58.602 [Open Access @J-STAGE]

Chihara T, Umezawa M, Miyata K, Sekiyama S, Hosokawa N, Okubo K, Kamimura M, Soga K: Biological deep temperature imaging with fluorescence lifetime of rare-earth-doped ceramics particles in the second NIR biological window. Scientific Reports, 9: 12806 (2019) https://doi.org/10.1038/s41598-019-49291-x [PubMed] [Open Access @NPG]

Umezawa M, Haruguchi S, Fukushima R, Sekiyama S, Kamimura M, Soga K: Rapid increase in transparency of biological organs by matching refractive index of media to cell membrane using phosphoric acid. RSC Advances, 9: 15269-15276 (2019) https://doi.org/10.1039/C9RA01445D [Open Access @RSC]

Kamimura M, Ueya Y, Takamoto E, Iso K, Yoshida M, Umezawa M, Soga K: Fluorescent polystyrene latex nanoparticles for NIR-II in vivo imaging. Journal of Photopolymer Science and Technology, 32(1): 93-96 (2019) https://doi.org/10.2494/photopolymer.32.93 [Open Access @J-STAGE]

Yeroslavsky G, Umezawa M, Okubo K, Nigoghossian K, Dung DTK, Kamimura M, Soga K: Photostabilization of indocyanine green dye by energy transfer in phospholipid-PEG micelles. Journal of Photopolymer Science and Technology, 32(1): 115-121 (2019) https://doi.org/10.2494/photopolymer.32.115 [Open Access @J-STAGE]

Sekiyama S, Umezawa M, Iizumi Y, Ube T, Okazaki T, Kamimura M, Soga K: Delayed increase in near-infrared fluorescence in cultured murine cancer cells labelled with oxygen-doped single-walled carbon nanotubes. Langmuir, 35(3): 831-837 (2019) https://doi.org/10.1021/acs.langmuir.8b03789 [PubMed]

Sekiyama S, Umezawa M, Kuraoka S, Ube T, Kamimura M, Soga K: Temperature sensing of deep abdominal region in mice by using over-1000 nm near-infrared luminescence of rare-earth-doped NaYF4 nanothermometer. Scientific Reports, 8: 16979 (2018) https://doi.org/10.1038/s41598-018-35354-y [PubMed] [Open Access @NPG]

Kamimura M, Matsumoto T, Suyari S, Umezawa M, Soga K: Ratiometric near-infrared fluorescence nanothermometry in the OTN-NIR (NIR II/III) biological window based on rare-earth doped β-NaYF4 nanoparticles. Journal of Material Chemistry B, 5(10): 1917-1925 (2017) https://doi.org/10.1039/c7tb00070g [PubMed]

梅澤雅和、新海雄介、小野田淳人、武田健、上村真生、曽我公平「動物体内におけるナノ粒子の未知なる動態メカニズムと検出技術改善のニーズ」バイオイメージング（日本バイオイメージング学会）、25(1): 22-27 (2016) [日本語]