Publications

Edo H, Itano R, Umezawa M: Long non-coding RNAs potentially suppressive for brain perivascular astrogliosis induced by environmental ultrafine particle matter. Envronmental Science and Pollution Research., 32: 25261–25271 (Oct 2025) https://doi.org/10.1007/s11356-025-37141-5 [PubMed] [Open Access @Springer Nature]

Priscilla S, Nagasawa R, Senthil Kumar S, Kasavaraju SC, Chandrakanth C, Sivakumar P, Bharat H, Muthulingam I, Umezawa M, Sheik Mohideen S: Polyethylene microplastics induce behavioural and developmental deficits in the Drosophila model. Toxicol. Environ. Health Sci., 17: 449-460 (Aug 2025) https://doi.org/10.1007/s13530-025-00272-w [Open Access @Springer Nature]

Kaumbekova S, Sakaguchi N, Miyamoto Y, Onoda A, Ishihara Y, Umezawa M: Effect of urban particulate matter on the secondary structure of albumin. Environ. Sci. Process. Impacts, 27: 892-900 (Mar 2025) https://doi.org/10.1039/D4EM00766B [PubMed] [Open Access @RSC]

Ranjan H, Kumar SS, Priscilla S, Swaminathan S, Umezawa M, Sheik Mohideen S: Polyethylene microplastics affect behavioural, oxidative stress, and molecular responses in the Drosophila model. Environ. Sci. Process. Impacts, 26: 2203-2214 (Oct 2024) https://doi.org/10.1039/D4EM00537F [PubMed] [Open Access @RSC]

Kaumbekova S, Amouei Torkmahalleh M, Umezawa M, Wang Y, Shah D: Effect of carbonaceous ultrafine particles on the structure and oligomerization of Aβ42 peptide. Environmental Pollution, 323: 121273 (Apr 2023) https://doi.org/10.1016/j.envpol.2023.121273  [PubMed]

Kaumbekova S, Amouei Torkmahalleh M, Sakaguchi N, Umezawa M, Shah D: Effect of ambient polycyclic aromatic hydrocarbons and nicotine on the structure of Aβ42 protein. Frontiers of Environmental Science & Engineering, 17: 15 (2023) https://doi.org/10.1007/s11783-023-1615-2 [Open Access]

Onoda A, Hagiwara S, Kubota N, Yanagita S, Takeda K, Umezawa M: A novel staining method for detection of brain perivascular injuries induced by nanoparticle: Periodic acid-Schiff and immunohistochemical double-staining. Frontiers in Toxicology, 4: 825984 (2022) https://doi.org/10.3389/ftox.2022.825984 [PubMed] [Open Access]

[Editorial] Umezawa M, Onoda A, El-Sayed YS: Mechanisms of developmental and reproductive toxicology of ultrafine and nano-sized particles. Frontiers in Toxicology, 4: 853506 (2022) https://doi.org/10.3389/ftox.2022.853506 [PubMed] [Open Access]

Tachibana K, Kawazoe S, Onoda A, Umezawa M, Takeda K: Effect of prenatal exposure to titanium dioxide nanoparticles on DNA methylation and gene expression profile in the mouse brain. Frontiers in Toxicology, 3: 705910 (2021) https://doi.org/10.3389/ftox.2021.705910 [PubMed] [Open Access]

Onoda A, Okamoto S, Shimizu R, El-Sayed YS, Watanabe S, Ogawa S, Abe R, Kamimura M, Soga K, Tachibana K, Takeda K, Umezawa M: Effect of carbon black nanoparticle on neonatal lymphoid tissues depending on the gestational period of exposure in mice. Frontiers in Toxicology, 3: 700392 (2021) https://doi.org/10.3389/ftox.2021.700392 [PubMed] [Open Access]

Elshony N, Nassar AMK, El-Sayed YS, Samak D, Noreldin A, Wasef L, Saleh H, Elewa YHA, Tawfeek SE, Saati AA, Batiha GE-S, Tomczyk M, Umezawa M, and Shaheen HM: Ameliorative role of cerium oxide nanoparticles against fipronil impact on brain function, oxidative stress, and apoptotic cascades in white albino rats. Frontiers in Neuroscience, 15: 651471 (2021) https://doi.org/10.3389/fnins.2021.651471 [PubMed] [Open Access @Frontiers]

Torkmahalleh MA, Akhmetvaliyeva Z, Omran AD, Omran FD, Kazemitabar M, Naseri M, Naseri M, Sharifi H, Malekipirbazari M, Adotey EK, Gorjinezhad S, Eghtesadi N, Sabanov S, Alastuey A, de Fátima Andrade M, Buonanno G, Carbone S, Cárdenas-Fuentes DE, Cassee FR, Dai Q, Henríquez A, Hopke PK, Keronen P, Khwaja HA, Kim J, Kulmala M, Kumar P, Kushta J, Kuula J, Massagué J, Mitchell T, Mooibroek D, Morawska L, Niemi JV, Ngagine SH, Norman M, Oyama B, Oyola P, Öztürk F, Petäjä T, Querol X, Rashidi Y, Reyes F, Ross-Jones M, Salthammer T, Savvides C, Stabile L, Sjöberg K, Söderlund K, Raman RS, Timonen H, Umezawa M, Viana M, Xie S: Global air quality and COVID-19 pandemic: Do we breathe cleaner air? Aerosol and Air Quality Research, 21(4): 200567 (2021) https://doi.org/10.4209/aaqr.200567 [Open Access]

Wasef L, Nassar AMK, El-Sayed YS, Samak D, Noreldin A, Elshony N, Saleh H, Elewa YHA, Hassan SMA, Saati AA, Hetta HF, Batiha GE, Umezawa M, Shaheen HM: The potential ameliorative impacts of cerium oxide nanoparticles against fipronil-induced hepatic steatosis. Scientific Reports, 11: 1310 (2021) https://doi.org/10.1038/s41598-020-79479-5 [PubMed] [Open Access @NPG]

Li YJ, Shimizu T, Shinkai Y, Ihara T, Sugamata M, Kato K, Kobayashi M, Hirata Y, Inagaki H, Uzuki M, Akimoto T, Umezawa M, Takeda K, Azuma A, Yamamoto M, Kawada T: Nrf2 lowers the risk of lung injury via modulating the airway innate immune response induced by diesel exhaust in mice. Biomedicines, 8(10): 443 (2020) https://doi.org/10.3390/biomedicines8100443 [PubMed] [Open Access]

Saleh H, Nassar AMK, Noreldin AE, Samak D, Elshony N, Wasef L, Elewa YHA, Hassan SMA, Saati AA, Hetta HF, Batiha GE, Umezawa M, Shaheen HM, El-Sayed YS: Chemo-protective potential of cerium oxide nanoparticles against fipronil-induced oxidative stress, apoptosis, inflammation and reproductive dysfunction in male white albino rats. Molecules, 25(15): 3479 (2020) https://doi.org/10.3390/molecules25153479 [PubMed] [Open Access]

Onoda A, Kawasaki T, Tsukiyama K, Takeda K, Umezawa M: Carbon nanoparticles induce endoplasmic reticulum stress around blood vessels with accumulation of misfolded proteins in the developing brain of offspring. Scientific Reports, 10: 10028 (2020) https://doi.org/10.1038/s41598-020-66744-w [PubMed] [Open Access @NPG]

[Review] Riediker M, Zink D, Kreyling W, Oberdörster G, Elder A, Graham U, Lynch I, Duschl A, Ichihara G, Ichihara S, Kobayashi T, Hisanaga N, Umezawa M, Cheng TJ, Handy R, Gulumian M, Tinkle S, Cassee F: Particle toxicology and health - where are we? Particle and Fibre Toxicology, 16: 19 (2019) https://doi.org/10.1186/s12989-019-0302-8 [PubMed] [Open Access @BMC]
> Particle toxicology
> Particle medicine
> Dynamic fate of inhaled nanoparticles in the lungs of rodents
> Interrelated concepts of exposure, dosimetry and dose-metrics for NP risk assessment
> The 5 Bs: Bioavailability, biopersistence, bioprocessing, biomodification, and bioclearance of nanoparticles and the role of the biomolecule corona
> Immunity and systemic responses
> Non-specific effects of particles
> Particles and the developing body
> Particles in the natural envirnment and links to human health
> Lessons from the past for future toxicological studies on big, small and variously shaped particles
> Risk management and governance for particles and fibres

[Chapter] Umezawa M, Takeda K: Automobile exhaust: Detrimental effects on pulmonary and extrapulmonary tissues and offspring. in: Nriagu J, (Ed.) "Encyclopedia of Environmental Health (2nd Ed.)", Vol. 1, pp.217-222; Published by Elsevier BV (Netherlands) (2019) https://doi.org/10.1016/B978-0-12-409548-9.11671-9 [Elsevier]

[Review] 梅澤雅和、小野田淳人「ナノ粒子の妊娠期曝露による次世代健康影響」日本小児禁煙研究会雑誌（日本小児禁煙研究会）、8(2): 64-67 (2018) [日本語]

Lebda MA, Sadek KM, Tohamy HG, Abouzed TK, Shukry M, Umezawa M, El-Sayed YS: Potential role of α-lipoic acid and Ginkgo biloba against silver nanoparticles-induced neuronal apoptosis and blood-brain barrier impairments in rats. Life Sciences, 212: 251-260 (2018) https://doi.org/10.1016/j.lfs.2018.10.011 [PubMed]

Samak DH, El-Sayed YS, Shaheen HM, El-Far AH, Onoda A, Abdel-Daim MM, Umezawa M: In-ovo exposed carbon black nanoparticles altered mRNA gene transcripts of antioxidants, proinflammatory and apoptotic pathways in the brain of chicken embryo. Chemico-Biological Interactions, 295: 133-139 (2018) https://doi.org/10.1016/j.cbi.2018.02.031 [PubMed]

Umezawa M, Onoda A, Korshunova I, Jensen ACØ, Koponen IK, Jensen KA, Khodosevich K, Vogel U, Hougaard KS: Maternal inhalation of carbon black nanoparticles induces neurodevelopmental changes in mouse offspring. Particle and Fibre Toxicology, 15: 36 (2018) https://doi.org/10.1186/s12989-018-0272-2 [PubMed] [Open Access @BMC]

Onoda A, Takeda K, Umezawa M: Dysregulation of major functional genes in frontal cortex by maternal exposure to carbon black nanoparticle is not ameliorated by ascorbic acid pretreatment. Science of The Total Environment, 634: 1126-1135 (2018) https://doi.org/10.1016/j.scitotenv.2018.04.016 [PubMed]

[Proc] 小野田淳人、梅澤雅和「大気環境と子どもの健康に関する最新の国際動向―Clean air for children―」日本幼少児健康教育学会第36回大会（春季：朝霞大会）発表抄録集、pp.80-81 (2018)

Umezawa M, Nakamura M, El-Ghoneimy AA, Onoda A, Shaheen HM, Hori H, Shinkai Y, El-Sayed YS, El-Far AH, Takeda K: Impact of diesel exhaust exposure on the liver of mice fed on omega-3 polyunsaturated fatty acids-deficient diet. Food and Chemical Toxicology, 111: 284-294 (2018) https://doi.org/10.1016/j.fct.2017.11.027 [PubMed]

Onoda A, Takeda K, Umezawa M: Pretreatment with N-acetyl cysteine suppresses chronic reactive astrogliosis following maternal nanoparticle exposure during gestational period. Nanotoxicology, 11(8): 1012-1025 (2017) https://doi.org/10.1080/17435390.2017.1388864 [PubMed]

Onoda A, Kawasaki T, Tsukiyama K, Takeda K, Umezawa M: Perivascular accumulation of β-sheet-rich proteins in offspring brain following maternal exposure to carbon black nanoparticles. Frontiers in Cellular Neuroscience, 11: 92 (2017) https://doi.org/10.3389/fncel.2017.00092 [PubMed] [Open Access @Frontiers]

[Proc] 小野田淳人、梅澤雅和「大気環境と子供の脳の発育」日本幼少児健康教育学会第35回大会（春季：世田谷大会）発表抄録集、pp.90-91 (2017)

Onoda A, Takeda K, Umezawa M: Dose-dependent induction of astrocyte activation and reactive astrogliosis in mouse brain following maternal exposure to carbon black nanoparticle. Particle and Fibre Toxicology, 14: 4 (2017) https://doi.org/10.1186/s12989-017-0184-6 [PubMed] [Open Access @BMC]

[Review] Umezawa M, Onoda A, Takeda K: Developmental toxicity of nanoparticles on the brain. Yakugaku Zasshi, 137(1): 73-78 (2017) https://doi.org/10.1248/yakushi.16-00214 [PubMed] [日本語]
> ナノ粒子の胎児移行のサイズ依存性
> ナノ粒子が胎児及び出生児の発達に及ぼす直接影響と間接影響
> ナノ粒子の妊娠期曝露が次世代中枢神経系に及ぼす影響
> ナノ粒子の妊娠期曝露が出生児の行動学的特性に及ぼす影響
> ナノ粒子の曝露による次世代影響の予防に向けた課題

[Review] 梅澤雅和、立花研、小野田淳人、武田健「大気中ナノ粒子の健康影響」環境技術（環境技術学会）、45(11) 特集『大気中の超微小粒子（ナノ粒子）』: 11-16 (2016)

Shaheen HM, Onoda A, Shinkai Y, Nakamura M, El-Ghoneimy AA, El-Sayed YS, Takeda K, Umezawa M: The ceramide inhibitor fumonisin B1 mitigates the pulmonary effects of low-dose diesel exhaust inhalation in mice. Ecotoxicology and Environmental Safety, 132: 390-396 (2016) https://doi.org/10.1016/j.ecoenv.2016.06.025 [PubMed]

[Notes] 小野田淳人、川崎平康、築山光一、武田健、梅澤雅和「超微小粒子の胎児期曝露に伴う脳血管周囲異常の赤外顕微法による可視化」バイオイメージング（日本バイオイメージング学会）、25(1): 1 (2016) [日本語} [日本語mirror]

Mitsunaga S, Umezawa M, Takeda K, Nakamura S: Maternal administration of nanomaterials elicits hemoglobin upregulation in the neonatal brain of non-human primates. Journal of Toxicological Sciences, 41(2), 265-271 (2016) https://doi.org/10.2131/jts.41.265 [PubMed] [Open Access @J-STAGE]

[Book] Li YJ, Umezawa M, Takizawa H, Takeda K, Kawada T (Eds.): PM2.5 -Role of Oxidative Stress in Health Effects and Prevention Strategy-. Nova Science Publishers, Inc. (NY, USA) (2015) [Book]

[Review] Umezawa M, Onoda A, Takeda K: Findings regarding the hazard assessment of nanoparticles and their effects on the next generation. in: Li YJ et al., (Eds.) "PM2.5 -Role of Oxidative Stress in Health Effects and Prevention Strategy-", Chapter 13, pp.159-175; Published by Nova Science Publishers, Inc. (NY, USA) (2015) [Book] [Free Download Available]
> The origins of concerns about the health effects of nanoparticles
> Findings regarding the hazard assessment of nanoparticles
> Developmental effect of environmentl factors - Developmental origins of health ad disease
> Developmental toxicity of nanoparticles - The effects of nanoparticles on the next generation
> Brain perivascular cells - Potentially the most sensitive markers for predicting toxicity of prenatal nanoparticle exposure

[Review] Onoda A, Umezawa M, Takeda K: The potential protective effect of antioxidants on nanoparticle toxicity. in: Li YJ et al., (Eds.) "PM2.5 -Role of Oxidative Stress in Health Effects and Prevention Strategy-", Chapter 15, pp.197-210; Published by Nova Science Publishers, Inc. (NY, USA) (2015) [Book] [Free Download Available]
> The mechanism of negative effects of nanoparticles through the induction of excessive reactive oxygen species
> The protective effect of antioxidant supplementation on nanoparticle toxicity (vitamin C, vitamin E, n-3 PUFA)

[Review] Umezawa M, Namba M: Fine and ultrafine particle risk management: Problems to be solved. in: Li YJ et al., (Eds.) "PM2.5 -Role of Oxidative Stress in Health Effects and Prevention Strategy-", Chapter 17, pp.227-240; Published by Nova Science Publishers, Inc. (NY, USA) (2015) [Book] [Free Download Available]
> Definition of the intended targets of nano-regulation
> Re-considering the mechanism of nanoparticle-induced toxicity for its regulation
> Establishing a method for assessment of adverse effect level
> Developing a highly sensitive and quantitative detection technology for nanomaterials
> Distinguishing exposure scenarios for each type of nanoparticle
> Are nanoparticles "unknown encounters"?
> Securing the independence of risk managers
> Development of risk communcation patterns to reduce communicator anxiety - A workshop study

Yokota S, Sato A, Umezawa M, Oshio S, Takeda K: In utero exposure of mice to diesel exhaust particles affects spatial learning and memory with reduced N-methyl-D-aspartate receptor expression in the hippocampus of male offspring. Neurotoxicology, 50: 108-115 (2015) https://doi.org/10.1016/j.neuro.2015.08.009 [PubMed]

[Proc] 梅澤雅和「miRNAの分析技術とバイオマーカーとしての可能性」第16回日本毒性学会生涯教育講習会、1-25 (2015)

El-Sayed YS, Shimizu R, Onoda A, Takeda K, Umezawa M: Carbon black nanoparticle exposure during middle and late fetal development induces immune activation in male offspring mice. Toxicology, 327: 53-61 (2015) https://doi.org/10.1016/j.tox.2014.11.005 [PubMed]

Tachibana K, Takayanagi K, Akimoto A, Ueda K, Shinkai Y, Umezawa M, Takeda K: Prenatal diesel exhaust exposure disrupts the DNA methylation profile in the brain of mouse offspring. Journal of Toxicological Sciences, 40(1): 1-11 (2015) https://pubmed.ncbi.nlm.nih.gov/25560391/ [PubMed] [Open Access @J-STAGE]

Shimizu R, Umezawa M, Okamoto S, Onoda A, Uchiyama M, Tachibana K, Watanabe S, Ogawa S, Abe R, Takeda K: Effect of maternal exposure to carbon black nanoparticle during early gestation on the splenic phenotype of neonatal mouse. Journal of Toxicological Sciences, 39(4): 571-578 (2014) https://doi.org/10.2131/jts.39.571 [PubMed] [Open Access @J-STAGE]

Onoda A, Umezawa M, Takeda K, Ihara T, Sugamata M: Effects of maternal exposure to ultrafine carbon black on brain perivascular macrophages and surrounding astrocytes in offspring mice. PLoS One, 9(4): e94336 (2014) https://doi.org/10.1371/journal.pone.0094336 [PubMed] [Open Access @PLoS]

[Notes] 梅澤雅和、報告：菊池美穂「PM2.5とナノ粒子～次世代へのリスクを減らすために知っておきたいこと～」ダイオキシン・環境ホルモン対策国民会議ニュース・レター、88, 13-15 (2014) [日本語]

[Proc] 梅澤雅和「大気中の小さな粒子（PM2.5）による健康影響を防ぐために」日本幼少児健康教育学会第32回大会（春季：千葉大会）発表抄録集、pp.14-15 (2014)

Umezawa M, Sekita K, Suzuki K, Kubo-Irie M, Niki R, Ihara T, Sugamata M, Takeda K: Effect of aerosol particles generated by ultrasonic humidifiers on the lung in mouse. Particle and Fibre Toxicology, 10: 64 (2013) https://doi.org/10.1186/1743-8977-10-64 [PubMed] [Open Access]

Yokota S, Hori H, Umezawa M, Kubota N, Niki R, Yanagita S, Takeda K: Gene expression changes in the olfactory bulb of mice induced by exposure to diesel exhaust are dependent on animal rearing environment. PLoS One, 8(8): e70145 (2013) https://doi.org/10.1371/journal.pone.0070145 [PubMed] [Open Access @PLoS]

[Notes] 梅澤雅和 「大気中の微小粒子（PM2.5）とナノ粒子の健康リスク」環境・衛生薬学トピックス（日本薬学会環境・衛生部会）、#36 [日本語]

[Review] 梅澤雅和「ディーゼル排ガス・大気中微小粒子の生体影響と測定の意義」第72回大気汚染測定調査結果報告書（大気汚染測定運動東京連絡会）、pp.27-29 (2013)

[Notes] 梅澤雅和「ナノ粒子の健康リスク（2）私たちはいかにリスクを回避できるのか」市民研通信（市民科学研究室・上田昌文ら編）、第17号＝通巻145号 (2013)

[Review] 梅澤雅和、武田健「PM2.5の健康影響について私たちが注意したいこと」科学（岩波書店）、83(4): 424-427 (2013)

Yokota S, Moriya N, Iwata M, Umezawa M, Oshio S, Takeda K: Exposure to diesel exhaust during fetal period affects behavior and neurotransmitters in male offspring mice. Journal of Toxicological Sciences, 38(1): 13-23 (2013) https://doi.org/10.2131/jts.38.13 [PubMed] [Open Access @J-STAGE]

Umezawa M, Tainaka H, Kawashima N, Shimizu M, Takeda K: Effect of fetal exposure to titanium dioxide nanoparticle on brain development - brain region information. Journal of Toxicological Sciences, 37(6): 1247-1252 (2012) https://doi.org/10.2131/jts.37.1247 [PubMed] [Open Access @J-STAGE]

[Notes] 梅澤雅和「大気中の微小な粒子と子どもの健康」子どものからだと心白書2012（子どものからだと心・連絡会議）、pp.38-40 (2012)

[Notes] 小野真理子、梅澤雅和、橋本奈緒美「第5回ナノテクノロジー国際シンポジウム－職業衛生と環境衛生参加報告」エアロゾル研究（日本エアロゾル学会）26(4), pp.374-376 (2011)

[Review] 梅澤雅和「ナノ材料による次世代健康影響とリスク管理への課題」科学（岩波書店）、82(10): 1098-1103 (2012)

[Proc] Umezawa M, Takeda K: Current research and prospect for health effects of nanoparticles on offspring. IOP Conference Series: Materials Science and Engineering, 18: 232001 (2011) [Open Access]
> Reasons for the focus on the effects on offspring
> Effects on offspring from maternal exposure to environmental particle matter
> Effects on offspring from maternal exposure to nanoparticulate titanium dioxide
> How nanoparticles substantially affect human health

Umezawa M, Sakata C, Tanaka N, Tabata M, Takeda K, Ihara T, Sugamata M: Pathological study for the effects of in utero and postnatal exposure to diesel exhaust on a rat endometriosis model. Journal of Toxicological Sciences, 36(4): 493-498 (2011) https://doi.org/10.2131/jts.36.493 [PubMed] [Open Access @J-STAGE]

Umezawa M, Kudo S, Yanagita S, Shinkai Y, Riki N, Oyabu T, Takeda K, Ihara T, Sugamata M: Maternal exposure to carbon black nanoparticle increases collagen type VIII expression in the kidney of offspring. Journal of Toxicological Sciences, 36(4): 461-468 (2011) https://doi.org/10.2131/jts.36.461 [PubMed] [Open Access @J-STAGE]

[Proc] Umezawa M, Sera M, Takeda K: A novel analysis tool to interpret microarray results using multiple gene annotation. In: Al-Mubaid H "Proceeding of 3rd International Conference on Bioinformatics and Computational Biology 2011 (BICoB-2011)", pp.24-29; Published by Curran Associates, Inc. (UK) (2011) [Proc]

[Chapter] Umezawa M, Takeda K: What does carbon nanomaterial cause in human health? in Sanders IJ and Peeten TL (Eds.) "Endometriosis: Symptoms, Diagnosis and Treatments", Chapter 15, pp.261-263; Published by Nova Science Publishers, Inc. (NY, USA) (2011)

[Chapter] Umezawa M, Takeda K: Automobile exhaust: Detrimental effects on pulmonary and extrapulmonary tissues and offspring. in: Nriagu J, (Ed.) "Encyclopedia of Environmental Health", Vol. 1, pp.247-252; Published by Elsevier BV (Netherlands) (2011)

[Review] Takeda K, Shinkai Y, Suzuki K, Yanagita S, Umezawa M, Yokota S, Tainaka H, Oshio S, Ihara T, Sugamata M: Health effects of nanomaterials on next generation. Yakugaku Zasshi, 131(2): 229-236 (2011) https://doi.org/10.1248/yakushi.131.229 [PubMed] [日本語]

[Notes] 梅澤雅和「カーボンナノチューブの吸入曝露はT細胞の働きを抑制する」ファルマシア（日本薬学会）、46(4): 361-362 (2010)

Suzuki T, Oshio S, Iwata M, Saburi H, Odagiri T, Udagawa T, Sugawara I, Umezawa M, Takeda K: In utero exposure to a low concentration of diesel exhaust affects spontaneous locomotor activity and monoaminergic system in male mice. Particle and Fibre Toxicology, 7: 7 (2010) https://doi.org/10.1186/1743-8977-7-7 [PubMed] [Open Access @BMC]

[Review] 新海雄介、梅澤雅和、武田健 「ナノマテリアルの次世代健康影響―脆弱性集団への影響」医学のあゆみ（医歯薬出版）、230(8): 512-516 (2009)

Shimizu M, Tainaka H, Oba T, Mizuo K, Umezawa M, Takeda K: Maternal exposure to nanoparticulate titanium dioxide during the perinatal period alters gene expression related to brain development in the mouse. Particle and Fibre Toxicology, 6: 20 (2009) https://doi.org/10.1186/1743-8977-6-20 [PubMed] [Open Access @BMC] ➡ プレスリリース「Nanotech particles affect brain development in mice」(July 28, 2009 @Phys.org)

[Review] Xu G, Umezawa M, Takeda K:  Early development origins of adult disease caused by malnutrition and environmental chemical substances.  Journal of Health Science, 55(1): 11-19 (2009) https://doi.org/10.1248/jhs.55.11 [Open Access @J-STAGE]
> Epidemiological evidence supporting a link between maternal malnutrition and adult disease
> Effect of maternal malnutrition: The thrifty phenotype hypothesis
> Critical period programming
> Effects of maternal exposure to diesel exhaust
> Effects of perinatal environment tobacco smoke exposure

Umezawa M, Sakata C, Tabata M, Tanaka N, Kudo S, Takeda K, Ihara T, Sugamata M: Diesel exhaust exposure enhances the persistence of endometriosis model in rats. Journal of Health Science, 54(4): 503-507 (2008) https://doi.org/10.1248/jhs.54.503 [Open Access @J-STAGE]