Publications

Umezawa M, Suyama F, Tachibana K, Onoda A, Takeda K: Plant-derived nanovesicle enhanced microribonucleic acid transfer from nasal cavity to the brain. Molecular Pharmaceutics, 22(11): 6964-6971 (Oct 2025) https://doi.org/10.1021/acs.molpharmaceut.5c00931 [Pubmed] [Open Access @ACS]

Kanbe A, Yokoi K, Umezawa M, Tsuchiya K, Aoki S: Synthesis of optically pure cyclometalated iridium(III) complex-peptide hybrids and their anticancer activity. European Journal of Inorganic Chemistry, 2024: e202300793 (2024) https://doi.org/10.1002/ejic.202300793

Takano Y, Umezawa M, Kubota N, Takeda K, Yanagita S: Effects of music exposure during pregnancy on maternal behavior in mother rats. Heliyon, 8: e10029 (2022) https://doi.org/10.1016/j.heliyon.2022.e10029 [PubMed]

Yamaguchi K, Yokoi K, Umezawa M, Tsuchiya K, Yamada Y, Aoki S: Design, synthesis, and anticancer activity of triptycene-peptide hybrids that induce paraptotic cell death in cancer cells. Bioconjugate Chemistry, 33(4): 691-717 (2022) https://doi.org/10.1021/acs.bioconjchem.2c00076 [PubMed] ➡ プレスリリース「優れた抗がん作用を示すトリプチセン-ペプチドハイブリッド化合物の創製に成功～プログラム細胞死誘導機構の解明に大きく寄与～」

Yokoi K, Yamaguchi K, Umezawa M, Tsuchiya K, Aoki S: Induction of paraptosis by cyclometalated iridium complex-peptide hybrids and CGP37157 via a mitochondrial Ca2+ overload triggered by membrane fusion between mitochondria and the endoplasmic reticulum. Biochemistry, 61(8): 639-655 (2022) https://doi.org/10.1021/acs.biochem.2c00061 [PubMed] [Open Access @ACS]

Balachandran C, Yokoi K, Naito K, Haribabu J, Tamura Y, Umezawa M, Tsuchiya K, Yoshihara T, Tobita S, Aoki S: Cyclometalated iridium(III)-cationic peptide hybrids trigger paraptosis in cancer cells via an intracellular Ca2+ overload from the endoplasmic reticulum and a decrease in mitochondrial membrane potential. Molecules, 26: 7028 (2021) https://doi.org/10.3390/molecules26227028 [PubMed] [Open Access]

Haribabu J, Tamura Y, Yokoi K, Balachandran C, Umezawa M, Tsuchiya K, Yamada Y, Karvembu R, Aoki S: Synthesis and anticancer properties of bis and mono(cationic peptide) hybrids of cyclometalated Ir(III) complexes: Effect of the number of peptide units on anticancer activity. European Journal of Inorganic Chemistry, 2021(18): 1796-1814 (2021) https://doi.org/10.1002/ejic.202100154 [Open Access @Wiley]

Sato E, Umezawa M, Miyajima A, Koishi N, Kanaya A, Yamanaka A, Fujimoto M, Ishii Y, Saito A, Inoue S, Mano Y, Suzuki T, Ozeki R, Ishii N, Komoda M: Efficacy and safety of a modified combination regimen of phenothrin and ivermectin lotion in patients with head lice in Tsukuba, Japan. Journal of Cutaneous Immunology and Allergy, 4(1): 4-12 (2021) https://doi.org/10.1002/cia2.12149 [Open Access @Wiley]

Komoda M, Yamaguchi S, Takahashi K, Yanase K, Umezawa M, Miyajima A, Yoshimasu T, Sato E, Ozeki R, Ishii N: Efficacy and safety of a combination regimen of phenothrin and ivermectin lotion in patients with head lice in Okinawa, Japan. Journal of Dermatology, 47(7): 720-727 (2020) https://doi.org/10.1111/1346-8138.15348 [PubMed]

Yokoi K, Balachandran C, Umezawa M, Tsuchiya K, Mitrić A, Aoki S: Amphiphilic cationic triscyclometalated iridium(III) complex-peptide hybrids induce paraptosis-like cell death of cancer cells via an intracellular Ca2+-dependent pathway. ACS Omega, 5(12): 6983-7001 (2020) https://doi.org/10.1021/acsomega.0c00337 [PubMed] [Open Access @ACS]

Tsuji M, Koriyama C, Ishihara Y, Yamamoto M, Yamamoto-Hanada K, Kanatani K, Bamai YA, Onishi K, Senju A, Araki S, Shibata E, Morokuma S, Sanefuji M, Kitazawa H, Saito M, Umezawa M, Onoda A, Kusuhara K, Tanaka R, Kawamoto T, Japan Environment & Children’s Study Group: Associations between metal levels in whole blood and IgE concentrations in pregnant women, based on data from the Japan Environment and Children's Study. Journal of Epidemiology, 29(12): 478-486 (2019) https://doi.org/10.2188/jea.je20180098 [PubMed] [Open Access @J-STAGE] ➡ プレスリリース「『妊婦の血液中金属濃度とIgE抗体の関係』について」（環境研）

[Proc] 梅澤雅和「発達期の脳に及ぼすカフェインの影響の網羅的文献調査（第2報）」日本幼少児健康教育学会第38回大会（秋季：広島大会）発表抄録集、pp.60-61 (2019)

Toyoda Y, Takada T, Umezawa M, Tomura F, Yamanashi Y, Takeda K, Suzuki H: Identification of hepatic NPC1L1 as an NAFLD risk factor evidenced by ezetimibe-mediated steatosis prevention and recovery. FASEB BioAdvances, 1(5): 283-295 (2019) https://doi.org/10.1096/fba.2018-00044 [PubMed] [Open Access @FASEB]

[Proc] 梅澤雅和、小野田淳人「発達期の脳に及ぼすカフェインの影響の網羅的文献調査」日本幼少児健康教育学会第36回大会（春季：朝霞大会）発表抄録集、pp.82-83 (2018)

[Proc] Ide H, Umezawa M, Ohwada H: Proposal of application method of inductive logic programming to microarray data. CSBio '17: Proceedings of the 8th International Conference on Computational Systems-Biology and Bioinformatics: 50-55 (2017) https://doi.org/10.1145/3156346.3156356 [CSBio @ACM]

Saleh HM, El-Sayed YS, Naser SM, Eltahawy AS, Onoda A, Umezawa M: Efficacy of α-lipoic acid against cadmium toxicity on metal ion and oxidative imbalance, and expression of metallothionein and antioxidant genes in rabbit brain. Environmental Science and Pollution Research, 24(31): 24593-24601 (2017) https://doi.org/10.1007/s11356-017-0158-0 [PubMed] [Open Access @Springer]

Abdel-Daim MM, Moustafa YM, Umezawa M, Ramana KV, Azzini E: Applications of antioxidants in ameliorating drugs and xenobiotics toxicity: Mechanistic approach. Oxidative Medicine and Cellular Longevity, 2017: 4565127 (2017) https://doi.org/10.1155/2017/4565127 [PubMed] [Open Access]

[Proc] Ide H, Umezawa M, Ohwada H: Function prediction of disease-related long intergenic non-coding RNA using random forest. CSBio '16: Proceedings of the 7th International Conference on Computational Systems-Biology and Bioinformatics: 58-62 (2016) https://doi.org/10.1145/3029375.3029384 [CSBio @ACM]

[Proc] 小野田淳人、梅澤雅和「脳内の老廃物排出に対する睡眠の効果ならびに出生前環境の関わり」日本幼少児健康教育学会第34回大会（春季：青山大会）発表抄録集、pp.34-35 (2016)

[Proc] Kubota N, Takano Y, Umezawa M, Yanagita S, Takeda K: Music facilitates brain development? -Research report: Effect of music during pregnancy on maternal behavior composed of interaction between mother and pups in rats-. Proceeding for the 33rd Meeting of Japanese Society of Health Education of Children (Spring Noda Meeting), pp.24-27 (2015)

[Notes] 梅澤雅和「第53回Society of Toxicology (SOT) 学術年会派遣報告①－miRNAとバイオマーカー、新しい扉を開く新技術は生まれるか－」毒性学ニュース（日本毒性学会）39(4): 59 (2014)

梅澤雅和、堀寛、内山真理子、二木力夫、柳田信也、武田健「マイクロアレイ－MeSH法を用いた妊娠前の脂質過剰摂取による肝臓遺伝子発現変動の解析」日本病態栄養学会誌（日本病態栄養学会）、17(3): 331-337 (2014)

Hori H, Umezawa M, Uchiyama M, Niki R, Yanagita S, Takeda K: Effect of high-fat diet prior to pregnancy on hepatic gene expression and histology in mouse offspring. Journal of Perinatal Medicine, 42(1): 83-91 (2014) https://doi.org/10.1515/jpm-2013-0091 [PubMed]

[Notes] 梅澤雅和「薬学・情報学・社会学をつないで切り拓く次世代健康科学」理大科学フォーラム（東京理科大学）30(6), pp.14-17 (2013)

Umezawa M, Saito Y, Tanaka-Hattori N, Takeda K, Ihara T, Sugamata M: Expression of profile of extracellular matrix and adhesion molecules in the development of endometriosis in a mouse model. Reproductive Sciences, 19(12): 1365-1372 (2012) https://doi.org/10.1177/1933719112450340 [PubMed]

Tainaka H, Takahashi H, Umezawa M, Tanaka H, Nishimune Y, Oshio S, Takeda K: Evaluation of the testicular toxicity of prenatal exposure to bisphenol A based on microarray analysis combined with MeSH annotation. Journal of Toxicological Sciences, 37(3): 539-548 (2012) https://doi.org/10.2131/jts.37.539 [PubMed] [Open Access @J-STAGE]

[Proc] 梅澤雅和「妊娠期の脂質摂取と小児の健康に関する基礎的研究」日本幼少児健康教育学会第30回記念大会（春季：野田大会）発表抄録集、pp.26-27 (2012)

Yanagita S, Kanemaru J, Ochiai H, Umezawa M, Takeda K: Short-term treadmill running increases expression of Δ-FosB in several brain regions. The Inaugural International Academy of Sportology, 62-67 (2011)

Takahashi H, Tainaka H, Umezawa M, Takeda K, Tanaka H, Nishimune Y, Oshio S: Evaluation of testicular toxicology of doxorubicin based on microarray analysis of testicular specific gene expression. Journal of Toxicological Sciences, 36(5): 559-567 (2011) https://doi.org/10.2131/jts.36.559 [PubMed] [Open Access @J-STAGE]

Umezawa M, Tanaka N, Takeda K, Ihara T, Sugamata M: Clarithromycin and telithromycin increases interleukin-10 expression in the rat endometriosis model. Cytokine, 55(3): 339-342 (2011) https://doi.org/10.1016/j.cyto.2011.05.014 [PubMed] 

[Notes] 梅澤雅和「サイトカイン発現調節による新たな治療戦略の展望－2011年学術集会参加記－」JSICR Newsletter（日本インターフェロン・サイトカイン学会）32, pp.8-9

[Chapter] Umezawa M, Takeda K, Ihara T, Sugamata M: Advantages and disadvantages of each animal model of endometriosis. in Mitchell LA (Ed.) "Endometriosis: Symptoms, Diagnosis and Treatments", Chapter 15, pp.261-263; Published by Nova Science Publishers, Inc. (NY, USA) (2011)

[Proc] Umezawa M, Sera M, Takeda K: A novel analysis tool to interpret microarray results using multiple gene annotation. Proceedings of 3rd International Conference on Bioinformatics and Computational Biology 2011 (BICoB-2011), pp.24-29 (2011)

[Review] Umezawa M, Takeda K, Ihara T, Sugamata M: Novel insights into the pathogenesis of endometriosis from a disease model induced by autotransplantation of endometrium. Inflammation and Regeneration, 30(2): 115-119 (2010) https://doi.org/10.2492/inflammregen.30.115 [Open Access @J-STAGE]
> Induced allergic reactions in the endometriosis model
> Upregulated expression of genes associated with cell adhesion in the early steps of pathophyciology of the endometriosis model
> A unique model of endometriosis
> Prospect for a novel strategy for prevention and treatment of endometriosis

Umezawa M, Tanaka N, Tainaka H, Takeda K, Ihara T, Sugamata M: Microarray analysis provides insight into early steps of pathophysiology of mouse endometriosis model induced by autotransplantation of endometrium. Life Sciences, 84(23-24): 832-837 (2009) https://doi.org/10.1016/j.lfs.2009.03.015 [PubMed] 

Umezawa M, Sakata C, Tanaka N, Kudo S, Tabata M, Takeda K, Ihara T, Sugamata M: Cytokine and chemokine expression in a rat endometriosis is similar to that in human endometriosis. Cytokine, 43(2): 105-109 (2008) https://doi.org/10.1016/j.cyto.2008.04.016 [PubMed]

[Proc] 梅澤雅和、坂田千佳、田中奈央美、田畑真佐子、武田健、内出一郎、森田峰人、井原智美、菅又昌雄 「子宮内膜症モデルラット実験系を用いた病態解析」エンドメトリオーシス研究会会誌（エンドメトリオーシス研究会）、28: 36-40 (2007) [日本語]