Magic is a feature new to Wynn Mafia 2, as an additional/alternative way to do various tasks with the game's more RPG elements.

In order to cast spells, players must have learned a spell and have the mana required to cast it. Spells can be learned through spell scrolls, which are widely available items. Mana can be obtained by consuming mana potions, another common item. Players will normally have a maximum mana of 3, although that can be increased through some items. Some roles possess the "magic user" trait, which raises their maximum mana to 9.

There are multiple classifications of spells based on their effects. Spells can be labeled positive, neutral, or negative as well as infliction, modification, or offensive. Some items or roles may impact specific types of spells, but not others.

Spells can be affected by spell power, a metric which determines the strength of a spell. Having a spell power above 0 will amplify the spell's effects, whereas a spell power below 0 will weaken the spell. Casting spells without a magic-type weapon equipped will cause spells to be cast at -2 power.

Spell power modifiers are listed below, followed by the list of spells.