The Invisible Lyme-Like Disease 

Borrelia miyamotoi

A Relapsing Fever 


UPDATE- May 2017 

Borrelia miyamotoi

Discovered In Ticks in Virginia & Maryland

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UPDATE- December 21, 2015

Borrelia miyamotoi Survives 

Blood Bank Storage Conditions

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UPDATE- Press Release

September 12, 2014

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It Looks Like Lyme, Acts Like Lyme, 

But, It’s Not Lyme

Lucy Barnes

Ticks responsible for transmitting Lyme disease may carry another organism that causes persistent infection in laboratory mice and prolonged, relapsing illness in humans.  A study to be released in October 2011, Humans infected with relapsing fever spirochete Borrelia miyamotoi, Russia, by Platonov AE, Karan LS, Kolyasnikova NM, Makhneva NA, Toporkova MG, Maleev VV, et al. states the infection may have negative health consequences, including a relapsing disease that may last for months.  

There are no tests to detect the infection, and a curative treatment protocol, if one exists, has yet to be established. 

In 1995 Japanese scientists proposed the name Borrelia miyamotoi for their newly discovered spirochete, strain HT31, and within a year constructed maps of the chromosome.   Since that time evidence of the organism has been detected in humans, ticks, birds and wildlife in Russia, Sweden, Germany, Czechia, Poland, Canada, and in several US states (MI, NY, RI, NJ, CT, CA).  

Human disease caused by B. miyamotoi has recently been studied in Russia and may, according to two Yale University researchers, explain the prolonged episodes of illness designated as "chronic Lyme disease". 

A Growing Concern

The Center for Wildlife at the University of Tennessee reported last year that 58% of the wild turkeys harvested by hunters from seven of its counties tested positive for exposure to the Borrelia miyamotoi spirochete during the 2009 spring and fall seasons.   Additionally, 70% of turkeys studied were “infested” with juvenile Lone-star ticks (Amblyomma americanum), one of the species known to carry the bacteria that causes relapsing illness.

Experts from Fisheries and Wildlife at the University of Michigan reported at the conclusion of their five-year study (2010) that transmission of Lyme and other diseases by several tick species is occurring, and B. miyamotoi has been detected in ticks and wildlife in Michigan. 

German scientists warn that unlike the Lyme disease spirochete, B. miyamotoi appears to be readily passed between generations of ticks.  Researchers in CT studying the 4-Poster Deer device, licensed and promoted by the American Lyme Disease Foundation (ALDF), determined the deer bait station was not associated with changes in the prevalence of infection with microorganisms among nymphal or adult ticks, including B. miyamotoi. 

According to the ALDF, one published study estimated that Lyme disease alone may cost society over two billion dollars a year, which raises concerns about the additional burden of more tick borne diseases for which there are no reliable tests and no known successful treatment protocols, including any of the 300+ known strains of Borrelia that may or may not cause human or animal disease. 

The Solution?

A Yale University entomologist and epidemiologist were recently awarded a $300,000 NIH grant to investigate the relationship between B. miyamotoi and other Borrelia species in order to develop improved diagnostic methods and to compare the frequency and clinical symptoms of B. miyamotoi infection with those of Lyme disease.  

The grant recipients, once strong promoters of the no such thing as “chronic Lyme disease” theory, report B. miyamotoi “causes persistent illness with relapsing fever symptoms”; therefore, they feel information is urgently needed because it is possible that “some prolonged episodes of illness attributed to Lyme disease and designated as "chronic Lyme disease" are due to B. miyamotoi infection.”

Symptoms and Treatment  

The new study by Platonov, et al. of patients with various tick borne infections included 17% who were infected with B. miyamotoi.  They reported the relapsing disease is characterized by aninfluenza-like illness, headache, chills, fatigue, vomiting, myalgias, neck stiffness, and a high fever that is relatively short in duration. 

Study patients relapsed without treatment. Only 9% of the B. miyamotoi cases studied reported a rash.  Acute B. miyamotoi infection can present more severely than the early stages of Lyme disease and it was clear that people can be infected with more than one disease after exposure to ticks. 

The time from tick bite to the onset of symptoms was longer, the time from symptom onset to hospital admission was shorter, and the hospital stay was notably longer for B. miyamotoi patients. The number of symptoms reported was greater for patients with B. miyamotoi infection, and a Jarisch-Herxheimer reaction was noted in 15% of the patients.  

When admitted to the hospital, the majority of patients were reported to have negative serology; however, some later converted to seropositive, and as with Lyme disease, some did not seroconvert.    

The study’s treatment protocol consisted of a trial of either 2 weeks of IV ceftriaxone (42 patients), or 2 weeks of oral Doxycycline (2 patients).  There is no test to determine a cure.  The time between relapses in B. miyamotoi infected patients averaged 9 days (range 2 days to 2 weeks), however, researchers felt early treatment may have prevented subsequent relapses for the majority of patients.

Researchers noted B. miyamotoi infection may cause substantial health problems given its relatively high incidence and its associated severity. Relapsing febrile episodes were only reported for B. miyamotoi patients as compared to patients with other tick borne illnesses.  

Such multiple disease episodes not only have an adverse effect on a patient’s health, but also may result in costly medical bills, many days or weeks of lost wages, and a medical misdiagnosis.  

Co-infection of B. miyamotoiwith other ixodid tick–transmitted agents may increase disease severity.  Additional problems that might occur with B. miyamotoi infection are ocular, neurologic, respiratory, cardiac, and pregnancy complications associated with relapsing fever, similar to what is found in Lyme disease patients.

Concern was expressed by study authors that patients may remain undiagnosed because of the nonspecific nature of the illness, which might be confused with viral infections or such tick-borne infections as Lyme disease, babesiosis, anaplasmosis, or ehrlichiosis- and because of the lack of laboratory tests for confirmatory diagnosis.


Testing for Borrelia miyamotoi

Igenex Lab- YES

Imugen Lab- YES

Quest- YES 

PCR- CPT Code- 87798

Labcorp- NO

~ ~ ~

Treatment Recommendations

Borrelia miyamotoi 

The new illness is caused by the bacteria known as Borrelia miyamotoi and has been found to be more resistant to antibiotic treatment. Source

Reported cases have been successfully treated with several antimicrobial regimens including ceftriaxone, doxycycline, and amoxicillin. Source

The most common antibiotic prescribed for people infected with B. miyamotoi is doxycycline. Another common antibiotic is intravenous ceftriaxone (two grams, once a day), provided that it is taken for two weeks.  Source

2-4 week course of doxycycline. Amoxicillin and ceftriaxone have also been used.  Source

Doxycycline 100 mg.- #2 twice daily. Add Omnicef 300mg, #2 twice daily for 21-28 days total. Wait 4 weeks and assess where you are.  

Forty of the 51 patients had received 2- to 4-week courses of oral doxycycline, seven had received amoxicillin (including three patients treated with one or two doses of ceftriaxone beforehand), and one received levofloxacin. Symptoms resolved in from 2 days to 1 week in 40 of the 42 patients for whom outcomes information was available.  Source


Additional Reading

Borrelia miyamotoi 

> miyamotoi Disease: Neither Lyme or Relapsing Fever 

Anxiety Caused by Borrelia miyamotoiB. miyamotoi- Confusion 

B. miyamotoi Survives Blood Bank Storage 

Borrelia miyamotoi 2015- 2017 Abstracts

Borrelia miyamotoi Named After 

More on B. miyamotoi 

Multiple Organisms In Rodents 

PR- The Invisible Disease 9/12/14

1995 Japan

http://www.ncbi.nlm.nih.gov/pubmed/7547303

1996 Japan

http://www.ncbi.nlm.nih.gov/pubmed/8877131

1996 Japan

http://www.ncbi.nlm.nih.gov/pubmed/8764474

Russian Ticks- Irkutsk City- 2015

http://www.ncbi.nlm.nih.gov/pubmed/26750571

Russian Ticks

http://www.ncbi.nlm.nih.gov/pubmed/20795483

Russia Testing

http://www.ncbi.nlm.nih.gov/pubmed/20734723

Russia Rash

http://www.ncbi.nlm.nih.gov/pubmed/21381356

Russian ticks

http://www.ncbi.nlm.nih.gov/pubmed/19198169

Small Mammals & Ticks- Croatia- 2015

http://www.ncbi.nlm.nih.gov/pubmed/26711522

Germany

http://www.ncbi.nlm.nih.gov/pubmed/21923267

Germany

http://www.ncbi.nlm.nih.gov/pubmed/17326945

Canada

http://www.ncbi.nlm.nih.gov/pubmed/21421790

Czechia

http://www.ncbi.nlm.nih.gov/pubmed/18062179

Sweden ticks

http://www.ncbi.nlm.nih.gov/pubmed/20844223

Sweden

http://www.ncbi.nlm.nih.gov/pubmed/12202571

Poland

http://www.ncbi.nlm.nih.gov/pubmed/20007765

Poland

http://www.ncbi.nlm.nih.gov/pubmed/18075156

Michigan  

http://www.ncbi.nlm.nih.gov/pubmed/20229127

California

http://www.ncbi.nlm.nih.gov/pubmed/16506458

http://www.ncbi.nlm.nih.gov/pubmed/15498172

New Jersey

http://www.ncbi.nlm.nih.gov/pubmed/16465748

Tennessee

http://www.ncbi.nlm.nih.gov/pubmed/21175079

Connecticut

http://www.ncbi.nlm.nih.gov/pubmed/12653133

Massachusetts

http://www.ncbi.nlm.nih.gov/pubmed/11158095

Virginia

"Borrelia miyamotoi and A. phagocytophilum were documented at 60% and 70% of the parks, respectively..."  [Eastern National Parks & Mid-Atlantic National Parks.]

https://www.ncbi.nlm.nih.gov/pubmed/?term=miyamotoi+Virginia

*** Pennsylvania & Maryland patients are reporting testing positive for B. miyamotoi.

*** PR From Columbia University- "Tests found B. microti present in a higher proportion of ticks in Suffolk County than Connecticut, including 17 vs. 7 percent of nymphal ticks."


 
























Updated June 2017

Lucy Barnes

AfterTheBite@gmail.com