Middlebrook was built in 1845.
Location: 4001 Middlebrook Pike, Knoxville
From the publication "The Future of Knoxville’s Past- Historic and Architectural Resources in Knoxville, Tennessee- Knoxville Historic Zoning Commission, October 2006," prepared by the Knoxville-Knox County Metropolitan Planning Commission:
“Middlebrook, 4001 Middlebrook Pike (1845). Middlebrook is one of the oldest frame homes in east Tennessee. It was built by Gideon Morgan Hazen” (p. 19).
There is a pretty good picture of Middlebrook on its Wikipedia.org page. Knox Heritage also has a good picture of Middlebrook in its Picasa web album of antebellum homes. Click here to see it.