Ophélia Gestin
Contact
INERIS, MIV/TEAM
Parc ALATA, BP2
5, rue Taffanel
60550 Verneuil en Halatte, France
Work experience
April 2023
October 2024
Postdoctoral researcher at INERIS in human toxicokinetic modelling, aimed at studying the toxicokinetics of various contaminants throughout the human lifespan, as well as the transfer of contaminants from mother to child; carried out as part of various French and European projects (PARC, EFSA, Neurophyto).
Acquisition of skills in human toxicokinetic modelling and parameters research.
Verneuil-en-Halatte, France
October 2019
December 2022
PhD in aquatic toxicology - Organotropism, toxicokinetics and fate of trace metals in the freshwater sentinel species Gammarus fossarum.
Acquisition of skills in aquatic ecotoxicology, radio-ecotoxicology and toxicokinetic modelling.
LIENSs (UMR 7266) - LBBE (UMR 5558) - INRAE Lyon-Villeurbanne
Evolution, Ecosystems, Microbiology, Modelling (E2M2) school
University of Lyon, Claude Bernard Lyon 1 (Villeurbanne, France)
January 2019
June 2019
Internship at IFREMER: Methodological development to study copper bioaccumulation in marine phytoplankton and its potential for trophic transfer.
Nantes, France
April 2018
June 2018
Internship at MMS: Characterization of a new strain of cyanobacteria and observation of cadmium stress.
Acquisition of skills in genetics and aquatic ecotoxicology.
Le Mans, France
Other professional experience
2022
2023
Junior board member of SEFA (Society for Fundamental and Applied Ecotoxicology)
2014
2018
Educational assistant in middle school (day school) and high school (boarding school) - 18 hours per week
2014
2017
Occasional hostess missions for street marketing campaigns
July 2016, 2017
and 2018
Hostess at the “Vieilles Charrues” Festival, Carhaix-Plouguer (France)
Education
2019
2022
PhD in aquatic toxicology - Organotropism, toxicokinetics and fate of trace metals in the freshwater sentinel species Gammarus fossarum.
Director: O. Geffard (INRAE Lyon-Villeurbanne)
Co-directors: C. Lopes (LBBE, Lyon) and T. Lacoue-Labarthe (LIENSs, La Rochelle)
Evolution, Ecosystems, Microbiology, Modelling (E2M2) school - University of Lyon, Claude Bernard Lyon 1 (Villeurbanne, France)
2017
2019
Master’s degree in toxicology and ecotoxicology
University of Le Mans (Le Mans, France)
2015
2017
Bachelor’s degree in Life Sciences, majoring in Cell Biology and Physiology
University of Western Brittany (Brest, France)
Training
2022
Certificate of First Aid
2021
Training in university teaching methods
2020
Winter PREDITOX School 2020 (Ecotoxicology & predictive modelling)
Theoretical and practical training for working with radioelements
Reproducible research: methodological principles for transparent science
'Research Ethics', Enhanced course (online course + case study)
2019
Scientific integrity in the research professions
2018
Certification Application of procedures in animal experimentation on small rodents
Professional skills
Modelling and statistics
Ordinary differential equation
Bayesian inference
Toxicokinetic modelling: one and multi-compartment models; dissolved and trophic pathways; invertebrates and humans
Technical and analytical
Conservation and handling of various biological models: prokaryotic and eukaryotic phototrophic organisms, small aquatic invertebrates and small rodents
Experimental design and handling; Decontamination, packaging and storage of consumables for trace metal quantification; Use of stable isotopes and radioisotopes; Control of experimental exposure conditions
Sample collection and analysis: Dissection, mineralization, gamma spectrometry, flow cytometry, vacuum filtration, ICP-MS, UV/vis spectrometry
Data analysis: data acquisition, formatting, analysis and interpretation of data; interpretation and presentation of research results
Language skills and software
French
English
Software
Environments
Video conferencing software
Mother tongue
Scientific English (reading, writing, speaking)
R, Mendeley, iMovie, Microsoft Office, Open Office, Slack, InterWinner, Moodle, MCSim, FileZilla
Mac and Windows
BigBlueButton, Jitsi, Skype, Teams, Zoom
Teaching and student supervision
2023
2022
2021
2020
Co-supervision of 1st-year AgroParisTech Master's students on a project entitled "Modelling the passage of neurotoxic pesticides through the Blood-Brain Barrier” (20h)
Lecturer in CM “Pharmacokinetic and dose-response models” M2 Master TES, Université Paris Cité (2h)
Proofreading of dissertations for 2nd-year Master GEEL student, La Rochelle University
Proofreading of dissertations for 3rd-year Bachelor Life sciences student, La Rochelle University
Proofreading of dissertations for 2nd-year Master GEEL student, La Rochelle University
Supervision of a 2nd year Master GEEL student, La Rochelle University (5.5 months)
Vacation teaching, TP Botany and Mycology (L2), La Rochelle University (44h)
Vacation teaching, TP Botany and Mycology (L2), La Rochelle University (28h)
Publications
Gestin, O., Lacoue-Labarthe, T., Coquery, M., Delorme, N., Garnero, L., Dherret, L., Ciccia, T., Geffard, O., Lopes, C., 2021. One and multi-compartments toxico-kinetic modeling to understand metals organotropism and fate in Gammarus fossarum. Environment International 156, 106625. https://doi.org/10.1016/j.envint.2021.106625
Astuto M.C., Di Nicola M.R., Tarazona J.V., Devos Y., Liem A.K.D., Kass G.E.N., Bastaki M., Schoonjans R., Maggiore A., Charles S., Ratier A., Lopes C., Gestin O., Roncaglioni A., Robinson T., Carnesecchi E., Dorne J.L.C.M. (2021). In silico methods for Ecological risk assessment: principles, tiered approaches, applications and future perspectives. Book chapter. Methods in Molecular Biology. https://doi.org/10.1007/978-1-0716-1960-5_23
Gestin, O., Lopes, C., Delorme, N., Garnero, L., Geffard, O., Lacoue-Labarthe, T. 2022. Organ-specific accumulation of cadmium and zinc in Gammarus fossarum exposed to environmentally relevant metal concentrations. Environ. Pollut. 308. https://doi.org/10.1016/j.envpol.2022.119625
Charles, S., Gestin, O., Bruset, J., Lamonica, D., Baudrot, V., Chaumot, A., Geffard, O., Lacoue-Labarthe, T., Lopes, C., 2022. Generic solving of physiologically-based kinetic models in support of next generation risk assessment due to chemicals. J. Explor. Res. Pharmacol. https://doi.org/10.1101/2022.04.29.490045
Di Nicola, M. R., Cattaneo, I., Nathanail, A. V., Carnesecchi, E., Chiara Astuto, M., Steinbach, M. Williams, A. J., Charles, S., Gestin, O., Lopes, C., Lamonica D., Tarazona, J. V., 2022. The use of new approach methodologies for the environmental risk assessment of food and feed chemicals. Curr. Opin. Environ. Sci. Health. https://doi.org/10.1016/j.coesh.2022.100416
Gestin, O., Lacoue-Labarthe, T., Delorme, N., Garnero, L., Geffard, O., Lopes, C., 2023. Influence of the exposure concentration of dissolved cadmium on its organotropism, toxicokinetic and fate in Gammarus fossarum. Environ. Int. 171. https://doi.org/10.1016/j.envint.2022.107673
Gestin, O., Lopes, C., Delorme, N., Garnero, L., Geffard, O., Lacoue-Labarthe, T., In prep. Accumulation efficiency of metals (Ag, Cd and Zn) from two type of food in Gammarus fossarum, soumis à Peer Community Journal - Ecotoxicology & Environmental Chemistry
Gestin, O., Lacoue-Labarthe, T., Delorme, N., Garnero, L., Geffard, O., Lopes, C., In prep. Comparison of the organotropism, toxico-cinétique and fate of cadmium between dissolved and trophic pathway in Gammarus fossarum, en préparation pour Environmental Science & Technology
Communications
Oral presentations
Gestin O., Lacoue-Labarthe T., Delorme N., Garnero L, Geffard O., Lopes C. (2022). Toxicokinetic modelling to understand the influence of exposure pathways on the distribution, toxicokinetic and fate of cadmium in the organs of Gammarus fossarum. Conférence Internationale des Sciences en Écologie, 21-25 Novembre 2022.
Gestin O., Lacoue-Labarthe T., Delorme N., Garnero L, Geffard O., Lopes C. (2022). Comparaison de l'organotropisme, de la toxico-cinétique et du devenir du cadmium (Cd) accumulé par voie dissoute ou trophique chez Gammarus fossarum. Réunion plénière du GDR Écotoxicologie Aquatique, 15-17 Novembre 2022.
Gestin O., Lacoue-Labarthe T., Delorme N., Garnero L, Geffard O., Lopes C. (2022). Comparaison de l'organotropisme, de la toxico-cinétique et du devenir du cadmium (Cd) accumulé par voie dissoute ou trophique chez Gammarus fossarum. Conférence de la Société Française d’Écotoxicologie Fondamentale et Appliquée (SEFA), 30 Juin-1er Juillet 2022.
Gestin O., Lacoue-Labarthe T., Geffard O., Lopes C. (2022). Comment la modélisation permet de comprendre les processus de bioaccumulation des métaux ? Journée DIPEE (Dispositif de Partenariat en Écologie et Environnement Nouvelle-Aquitaine - Centre-val-de-Loire) à l'Université de Poitiers, 2 Juin 2022.
Gestin O., Lopes C., Delorme N., Garnero L, Geffard O., Lacoue-Labarthe T. (2022). Organotropism, bioaccumulation and fate of cadmium (Cd) and zinc (Zn) in Gammarus fossarum after exposure to environmental concentrations. 32ème Conférence annuelle européenne de la SETAC, 15-19 Mai 2022.
Gestin O., Lopes C., Delorme N., Garnero L, Geffard O., Lacoue-Labarthe T. (2021). Effet de la concentration d'exposition en cadmium (Cd) sur son organotropisme, sa toxico-cinétique et son devenir chez Gammarus fossarum. Réunion plénière du GDR Écotoxicologie Aquatique, 23-25 Novembre 2021.
Gestin O., Lopes C., Bourlier V., Delorme N., Garnero L, Geffard O., Lacoue-Labarthe T. (2021). L'organotropisme des métaux chez Gammarus fossarum, à des concentrations environnementales : modélisation toxico-cinétique multi-compartiments. Conférence de la Société Française d’Écotoxicologie Fondamentale et Appliquée (SEFA) (virtual), 28-29 Juin 2021. (Winner of the “Prize for the best oral communication”, selected by the SEFA 2021 Scientific Council and awarded by the Rovaltain Foundation).
Gestin O., Lopes C., Bourlier V., Delorme N., Garnero L, Geffard O., Lacoue-Labarthe T. (2021). La modélisation toxico-cinétique pour comprendre et formaliser le devenir de métaux au sein des organes d’un invertébré aquatique, Gammarus fossarum. Colloque conjoint (ECOTOQ, Chapitre Saint Laurent, ECOBIM, PURE) en écotoxicologie 2021 : Les enjeux de la contamination urbaine sur la santé environnementale (virtual), 31 Mai – 03 Juin 2021.
Gestin O., Lopes C., Bourlier V., Delorme N., Garnero L, Geffard O., Lacoue-Labarthe T. (2021). Accumulation, fate and effects of metals contaminants in the sentinel species Gammarus fossarum. 2ème édition de la Journée des thèse d'INRAE-Lyon Villeurbanne (virtual), 03-04 Mai 2021.
Gestin O., Lacoue-Labarthe T., Coquery M., Delorme N., Dherret L., Ciccia T., Geffard O., Lopes C. (2021). Use of one and multi-compartments toxico-kinetic modelling to understand Cd and Hg’s organotropism and fate in Gammarus fossarum. 31ème Conférence annuelle européenne de la SETAC (virtual), 03-06 Mai 2021.
Posters
Dussauçoy R., Gestin O., Billat P.-A., Piccini B., Hinfray N., Chadili E., Brion F., Beaudouin R. (2023). Améliorer l’évaluation des perturbateurs endocriniens agissant sur l’aromatase cérébrale grâce à la modélisation PBTK-TD chez l’embryon de poisson zèbre. Conférence de la Société Française d’Écotoxicologie Fondamentale et Appliquée (SEFA), 5-6 Juillet 2023.
Gestin O., Lacoue-Labarthe T., Delorme N., Garnero L, Geffard O., Lopes C. (2022). Influence of the exposure concentration of dissolved cadmium on its organotropism, toxico-kinetics and fate in Gammarus fossarum. 32ème Conférence annuelle européenne de la SETAC, 15-19 Mai 2022.
Gestin O., Lopes C., Delorme N., Garnero L, Geffard O., Lacoue-Labarthe T. (2022). Assimilation efficiency of cadmium (Cd) and influence of the exposure pathways on its distribution, toxico-kinetic and fate in the organs of Gammarus fossarum. 32ème Conférence annuelle européenne de la SETAC, 15-19 Mai 2022.
Gestin O., Lopes C., Bourlier V., Delorme N., Garnero L, Geffard O., Lacoue-Labarthe T. (2021). One-compartment toxicokinetic models to predict metals organotropism in Gammarus fossarum, at environmental concentrations. 31ème Conférence annuelle européenne de la SETAC (virtual), 03-06 Mai 2021.
Science vulgarisation
2023
Co-wrote a popular science article entitled “les substances perfluoroalkylées (pfas) : quel risque ces « polluants éternels » font-ils peser sur l’environnement ?” for the "Ecotoxicologie.fr" website (link)
Participation in the “Moi étudiant.e dans 3 ans” workshops organized by La Rochelle Université's orientation and integration center: a time for exchanges with high school students to help them build their study project and feel more involved in their orientation, through the testimonies of (post)doctoral students
2022
Participation in the “Cordée de la réussite - Cap Science” workshops organized by La Rochelle University's orientation and integration center: screening of the film produced as part of the “Film [pas trop] scientifique” festival, and discussions with secondary school students
Participation in the round table at the “Pars en these” event, organized by ED E2M2 (Lyon 1 University): information for Bachelor's and Master's students on life as a doctoral student, and answers to questions they may have
2021
Production of the short film “Un gammare, et ça repart!” for the 20th edition of the “Film [pas trop] scientifique” festival, organized by ADOCs (Association of doctoral students and young researchers at La Rochelle University) (Link) - Winner of the “Best scientific popularization price”, selected by the jury
Recording of a podcast for the program “LIttoral, ENvironnement & Sociétés”, presented by Gaëlle de Christen (radio RCF) (Link)
Participation in the round table at the “Pars en these” event, organized by ED E2M2 (Lyon 1 University): information for Bachelor's and Master's students on life in a PhD program, and answers to questions they may have
Participation in webinar n°2 “Les pieds dans l'eau : du laboratoire au terrain partageons notre savoir” organized by Réseaux Rivière TV and H2O'Lyon. Title: “Comment bien mesurer la bioaccumulation des contaminants métalliques en rivière ? TOP CHEF : ce soir c’est gammare fourré au Cadmium ! Faut-il prendre l’aile ou la cuisse ?” (Link)
Application to the Lyon selection rounds for the 2021 edition of MT180 (Link)