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Contact
Contact
INERIS, MIV/TEAM
Parc ALATA, BP 2
5, rue Taffanel
60550 Verneuil en Halatte, France
PhD project
PhD project
Title: Inter-species extrapolation using PBPK modeling in order to support a chemicals mixture risk assessment.
Title: Inter-species extrapolation using PBPK modeling in order to support a chemicals mixture risk assessment.
Risk assessment of the effects on human health of exposure to chemical substances or mixtures of substances is usually based on very heterogeneous and limited data. Thus, it is often necessary to analyze and interpret together data from different species (mouse and human) and different biological levels (organism and cell). The objective of this thesis is to develop physiologically based toxicokinetic models (called PBTK models) to allow cross-species and cross-biological level extrapolations inherent to risk assessments. We will particularly focus on a risk assessment of a mixture of 19 (families of) environmental contaminants measured in the breast milk of lactating women from the ContaLait study. A generic PBPK model adapted to rodents and humans has been previously developed by the TEAM unit, and will be extended for the population subgroups considered here (young breastfed children and lactating women). In particular, models will be developed for the lactating mouse, the breastfed pup, and the lactating infant.
Work experience
Work experience
November 2022
(in progress)
PhD. Student in Ecotoxicology and Toxicology Modelling
Supervisors: Dr. Florence Zeman & Dr. Karen Chardon
INERIS, Modelisation and Experimental Toxicology (TEAM)
Verneuil-en-Halatte, Fr
Project : PBPK Modelling of 19 (families of) substances in different subgroups (breastfed pup, lactating mouse) in order to estimate chemical exposition of lactating mothers by reverse dosimetry and interspecies extrapolation.
January 2022
July 2022
Research intern in Pharmacology and Virology
Supervisors : Pr. Caroline Solas
AP-HM – La Timone, Toxicology and Pharmacokinetic team
UVE (Emerging viruses unity) – IRD_190 – Inserm_1207
EFS – IRBA
Marseille, Fr
Projects : PBPK modelling of favipiravir describing plasma and tissue kinetics in Cynomolgus Fascicularis monkeys in order to facilitate Human extrapolations during efficacy test against emerging viruses. Bio-distribution analysis in monkey and golden hamster (cricetus auratus) using HPLC-MS/MS.
January 2021
July 2021
Supervisors : On demand
French Ministry of Defense - DGA mNRBC (Direction Générale de l’Armement maîtrise du risque chimique)
TOGA
Alfortville, Fr
Project : Development of a laboratory species PBTK-TD model during a toxicokinetic study of organophosphorus chemical war agents.
April 2020
June 2020
Supervisor : Dr. Chadi Abbara PharmD. PhD.
Angers’ Hospital, Toxicology & Pharmacology team
Project: Bibliographical evaluation of biological and physio-pathological covariates that can alter cytarabine’s kinetic profile during an in vitro pharmacokinetic analysis of its degradation data.
Education and training
Education and training
November 2022
(in progress)
PhD Student in toxicokinetic modelling
INERIS, Doctoral School STS ED 585 at Jules Vernes Picardie University (Verneuil-en-Halatte, Fr)
2021-2022
MSc in Pharmacokinetics
Aix-Marseille University, La Timone Pharmacy campus, France
2020-2021
MSc in Human and Environmental Toxicology
University of Angers, France
2015-2019
Bachelor’s degree in Cellular and Molecular Biology and Physiology specialized in Cancerology and Toxicology
University of Angers, France
2014-2015
1st Year of Medical studies
University of Angers, France
Language skills
Language skills
French: Mother tongue
English: Upper intermediate level
Spanish: Upper intermediate level
Chinese: Basics
Russian: Basics
Software
Software
Coding: Python, R, NONMEM, ACSL, MC Sim
PK softwares: Monolix Suite, PKSim, GastroPLUS
Other: Microsoft Office Suite, QGIS, Maltego XL, Affinity Designer/Photo
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