Embedded Files
2015 - 2017
Integrating toxicokinetics in chemical risk assessment: application to human, animal and environmental risk assessment
Integrating toxicokinetics in chemical risk assessment: application to human, animal and environmental risk assessment
The project
The project
The overall objective of the contract was to develop tools and models to integrate TK data and predict TK parameters for human health, animal health and environmental risk assessment of single and multiple chemicals.
METO was in charge of the development and application of TK tools and models for environmental risk assessment of single and multiple chemicals (Objective 3). The aim was three-fold:
Review available tools and models to integrate TK data in environmentalrisk assessment of chemicals including biologically and physiologically-based models, online tools, software and databases.
Data collection of biological, physiological and toxicological variables to calibrate and develop TK tools and biologically-based models for environmentalrisk assessment of single chemicals.
Development of TK tools and biologically-based models for environmentalrisk assessment of multiple chemicals.
METO developped a generic PBTK model for four species of fish, rainbow trout, three-spined stickleback, fathead minnow and zebrafish. The PBTK model was applied to ten single substances (Grech et al., 2019).
Toxicokinetic interactions were included in the PBTK model for risk assessment of multiple chemicals. Three case studies of mixtures were selected, melamine and cyanuric acid, chlorpyrifos and atrazine, chlorpyrifos and pyrethroids.
R code and scripts are available on Zenodo : https://zenodo.org/record/2609136#.XowzZ0E682w
Related articles
Related articles
Tebby C., Brochot C., Dorne J.-L., Beaudouin R., 2019. Investigating the interaction between melamine and cyanuric acid using a Physiologically-Based Toxicokinetic model in rainbow trout. Toxicology and Applied Pharmacology 370, 184-195.
Grech A, Tebby C, Brochot C, Bois FY, Bado-Nilles A, Dorne JL, Quignot N, Beaudouin R. 2019. Generic physiologically-based toxicokinetic modelling for fish: Integration of environmental factors and species variability. Science of The Total Environment. Volume 651, Part 1, Pages 516-531
Grech A, Brochot C, Dorne JL, Quignot N, Bois FY, Beaudouin R. Toxicokinetic models and related tools in environmental risk assessment of chemicals. Sci Total Environ. 2016 Nov 11. pii: S0048-9697(16)32332-4. doi: 10.1016/j.scitotenv.2016.10.146.
Page updated
Google Sites
Report abuse