Claudia Ileana Cappelli

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Postdoctoral Project

The LIFE VERMEER project (integrating VEGA, toxRead, MERLIN-Expo, and ERICA in a platform for risk assessment and substitution of risky substance) aims at the substitution of chemicals. The main objectives of this project are:

• • To implement a program, called ToxEraser, to substitute risky chemicals. This program will identify chemical moieties and features associated to the adverse effect of the chemicals, suggesting candidate substitutes.

  • To implement a program, called SPHERA, to merge the VEGA software for hazard evaluation with the MERLIN-Expo software for exposure assessment.

  • To implement within SPHERA a tool for the integrated assessment of human and environmental risks, suitable for regulatory contexts. To validate the mentioned software with six case studies: food contact materials, biocides, petroleum and oil fraction, greener solvents, dispersants, cosmetics.

Within the LIFE VERMEER project, I will contribute to the development of Quantitative structure-activity relationships for the prediction of toxicokinetic end (eco)toxicological properties and I will work on the SPHERA risk assessment tool to integrate risk factors into a single decision-making index.

Recent publications

• • Croce, R., Cinà, F., Lombardo, A., Crispeyn, G., Cappelli, C. I., Vian, M., Maiorana, S., Benfenati, E., Baderna, D. (2017). Aquatic toxicity of several textile dye formulations: Acute and chronic assays with Daphnia magna and Raphidocelis subcapitata. Ecotoxicology and Environmental Safety, 144, 79-87.

  • Drgan, V., Župerl, Š., Vračko, M., Cappelli, C. I., & Novič, M. (2017). CPANNatNIC software for counter-propagation neural network to assist in read-across. Journal of Cheminformatics, 9(1), 30

  • Pizzo, F., Lombardo, A., Manganaro, A., Cappelli, C. I., Petoumenou, M. I., Albanese, F., Roncaglioni, A., Brandt, M., Benfenati, E. (2016). Integrated in silico strategy for PBT assessment and prioritization under REACH. Environmental research, 151, 478-492.

  • Cappelli, C. I., Cassano, A., Golbamaki, A., Moggio, Y., Lombardo, A., Colafranceschi, M., & Benfenati, E. (2015). Assessment of in silico models for acute aquatic toxicity towards fish under REACH regulation. SAR and QSAR in Environmental Research, 26(12), 977-999.

  • Cappelli, C. I., Benfenati, E., & Cester, J. (2015). Evaluation of QSAR models for predicting the partition coefficient (logP) of chemicals under the REACH regulation. Environmental research, 143, 26-32.

  • Benfenati, E., Roncaglioni, A., Petoumenou, M. I., Cappelli, C. I., & Gini, G. (2015). Integrating QSAR and read across for environmental assessment. SAR and QSAR in Environmental Research, 26(7-9), 605-618.

  • Toropov, A. A., Toropova, A. P., Cappelli, C. I., & Benfenati, E. (2015). CORAL: model for octanol/water partition coefficient. Fluid Phase Equilibria, 397, 44-49.

Detailed curriculum vitae