OpenRiskNet

OpenRiskNet is a 3 year project funded under the Horizon 2020 EINFRA-22-2016 Programme.

The main objective is to provide an open e-Infrastructure providing resources and services to a variety of communities requiring risk assessment, including chemicals, cosmetic ingredients, therapeutic agents and nanomaterials. OpenRiskNet will work with a network of partners, organized within an Associated Partners Programme.

METO worked on a case-study on toxicokinetics and reverse dosimetry and was in charge of testing and checking the online tool, accessible through Jaqpot APIs and theJaqpot user-friendly GUI for simulations. This tool is a web interface to physiologically-based pharmacokinetic (PBPK) models for forward and reverse dosimetry calculations, for use in risk assessment to help with in vitro to in vivo extrapolations or interspecies extrapolations. The tool integrates the httk R package, the PKSim software tool and provides means for developing and deploying user-defined models in the R language. METO tested the tool using several reference chemicals or drugs: Imazalil for the httk model, Theophylline for the PKSim model, and Diazepam and Chlorpyrifos in rainbow trout for the user-defined models.