Florence Zeman

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Research interests

I work mainly on reverse dosimetry or exposure reconstruction using toxicokinetic and PBPK models in Human Biomonitoring studies (HBM). I am involved currently in the European project on early life exposome HELIX. I work also in the Elfe project and is implicated as coordinator of the team working on the assessment of exposure to environmental pollutants.

Recent publications

• • Fournier K, Tebby C, Zeman F, Glorennec P, Zmirou-Navier D, Bonvallot N. 2016. Multiple exposures to indoor contaminants: Derivation of benchmark doses and relative potency factors based on male reprotoxic effects. Regulatory toxicology and pharmacology : RTP 74:23-30.

  • Willemin ME, Desmots S, Le Grand R, Lestremau F, Zeman FA, Leclerc E, et al. 2016. Pbpk modeling of the cis- and trans-permethrin isomers and their major urinary metabolites in rats. Toxicol Appl Pharmacol 294:65-77.

  • Vrijheid M, Slama R, Robinson O, Chatzi L, Coen M, van den Hazel P, et al. 2014. The human early-life exposome (helix): Project rationale and design. Environmental Health Perspectives 122:535-544.

  • Zeman FA, Boudet C, Tack K, Floch Barneaud A, Brochot C, Péry ARR, et al. 2013. Exposure assessment of phthalates in french pregnant women: Results of the elfe pilot study. International Journal of Hygiene and Environmental Health 216:271-279.

  • Pery ARR, Brochot C, Zeman FA, Mombelli E, Desmots S, Pavan M, et al. 2013. Prediction of dose-hepatotoxic response in humans based on toxicokinetic/toxicodynamic modeling with or without in vivo data: A case study with acetaminophen. Toxicology Letters 220:26-34.

  • Ulaszewska MM, Ciffroy P, Tahraoui F, Zeman FA, Capri E, Brochot C. 2012. Interpreting pcb levels in breast milk using a physiologically based pharmacokinetic model to reconstruct the dynamic exposure of italian women. J Expos Sci Environ Epidemiol 22:601-609.

  • Audebert M, Zeman F, Beaudoin R, Pery A, Cravedi JP. 2012. Comparative potency approach based on h2ax assay for estimating the genotoxicity of polycyclic aromatic hydrocarbons. Toxicology and Applied Pharmacology 260:58-64.

  • Vandentorren S, Zeman F, Morin L, Sarter H, Bidondo M-L, Oleko A, et al. 2011. Bisphenol-a and phthalates contamination of urine samples by catheters in the elfe pilot study: Implications for large-scale biomonitoring studies. Environmental Research 111:761-764.