Cleo Bodin (Tebby)

Contact

Research interests

I work as a modeller and an applied statistician in the TEAM team, in the field of quantitative AOPs, dose-response analysis of single compound or mixture experiments, PBPK modelling, SAR and QSAR modelling, multivariate analysis of mesocosm data, and collecting and analysing data from the US EPA’s ToxCast database.

I currently coordinate a workpackage focussed on toxicologcal assessement in the Twinloop project, an EFSA-funded project on further development of TKPlate  and contribute to an EFSA-funded  project on update of AOP3. I have been involved in the  EUToxRisk 21  project for quantitative AOP modelling the EuroMix for PBPK modelling and OpenRiskNet projects.

Selected publications

• • Tebby, C., J. Caudeville, Y. Fernandez and C. Brochot (2022). "Mapping blood lead levels in French children due to environmental contamination using a modeling approach." Science of The Total Environment 808: 152149.

  • Tebby, C., W. Gao, J. Delp, G. Carta, W. van der Stel, M. Leist, P. Jennings, B. van de Water and F. Y. Bois (2022). "A quantitative AOP of mitochondrial toxicity based on data from three cell lines." Toxicology in Vitro 81: 105345.

  • Marchand, A.; Tebby, C.; Beaudouin, R.; Catteau, A.; Porcher, J.-M., Turiès, C.; Bado-Nilles, A., Reliability evaluation of biomarker reference ranges for mesocosm and field conditions: cellular innate immunomarkers in Gasterosteus aculeatus, Science of the Total Environment Volume 698, 1 January 2020, 13433.

  • Grech A, Tebby C, Brochot C, Bois FY, Bado-Nilles A, Dorne JL, Quignot N, Beaudouin R. 2019. Generic physiologically-based toxicokinetic modelling for fish: Integration of environmental factors and species variability. Science of The Total Environment. Volume 651, Part 1, Pages 516-531.

  • Tebby C., Brochot C., Dorne J.-L., Beaudouin R., 2019. Investigating the interaction between melamine and cyanuric acid using a Physiologically-Based Toxicokinetic model in rainbow trout. Toxicology and Applied Pharmacology 370, 184-195.

  • Zgheib E, Gao W, Limonciel A, Aladjov H, Yang H, Tebby C, Gayraud G, Jennings P, Sachana M, Beltman JB, Bois FY. Application of three approaches for quantitative AOP development to renal toxicity. Computational Toxicology, Volume 11, August 2019, Pages 1-13.

  • Nathalie Hinfray, Cleo Tebby, Benjamin Piccini, Gaelle Bourgine, Selim Aït-Aïssa, Jean-Marc Porcher, Farzad Pakdel, François Brion. 2018. Mixture concentration-response modeling reveals antagonistic effects of estradiol and genistein in combination on brain aromatase gene (cyp19a1b) in zebrafish. International Journal of Molecular Sciences. 19, 1047.

  • Tebby C, Joachim S, Van den Brink PJ, Porcher JM, Beaudouin R. 2017. Analysis of community-level mesocosm data based on ecologically meaningful dissimilarity measures and data transformation.  Environmental Toxicology and Chemistry. Volume 36, Issue 6, pp. 1667–1679.

  • Bois FY, Golbamaki-Bakhtyari N, Kovarich S, Tebby C, Gabb HA, Lemazurier E. 2017. High-Throughput Analysis of Ovarian Cycle Disruption by Mixtures of Aromatase Inhibitors. Environ Health Perspect. Volume 125, issue 7, pp 077012.

  • Hinfray N, Tebby C, Garoche C, Piccini B, Bourgine G, Aït-Aïssa S, Kah O, Pakdel F, Brion F. Additive effects of levonorgestrel and ethinylestradiol on brain aromatase (cyp19a1b) in zebrafish specific in vitro and in vivo bioassays. Toxicol Appl Pharmacol. 2016 Aug 1;307:108-114.

  • Tebby C, Mombelli E. 2013. Modelling Structure Activity Landscapes with Cliffs: a Kernel Regression-Based Approach. Molecular Informatics 32, 609-623.

  • Tebby C, Mombelli E. A Kernel-Based Method for Assessing Uncertainty on Individual QSAR Predictions. Mol. Inform. 31, 741-751.

  •  Tebby C, Mombelli E, Pandard P, Péry ARR. Exploring an ecotoxicity database with the OECD (Q)SAR Toolbox and DRAGON descriptors in order to prioritise testing on algae, daphnids, and fish. Science of the Total Environment, 409, 3334-3343.