Ghislaine Lacroix

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Présentation

Ghislaine LACROIX, Ph.D. in “Fundamental and Applied Toxicology” at the university of Denis Diderot (Paris 7-France), is a senior research scientist involved in respiratory toxicity. She is conducting studies to evaluate the effects of inhaled pollutants (gases, aerosols, (nano)particles) on health. One of the important aspects of her work is the promotion of alternative methods (in vitro and in silico) to limit the use of animal experimentation, which echoes the growing societal concern on this issue.

Since 2005, she has participating in various European projects related to the safety of nanomaterials (Nanosafe, Nanoreg…). 

Between 2007 and 2017, she has been member of (French) observatory for micro and nanotechnologies. 

She is currently participating in the OECD project 4.146 TG on “Toxicokinetics to accommodate testing of nanoparticles “ and is member of selection committee “contaminants, ecosystems and health” for the French National Research Agency.

Publications

• Madiedo-Podvrsan S, Sebillet L, Martinez T, Bacari S, Zhu F, Cattelin M, Leclerc E, Merlier F, Jellali R, Lacroix G, Vayssade M. Development of a lung-liver in vitro coculture model for inhalation-like toxicity assessment. Toxicol In Vitro. 2023 Oct;92:105641. doi: 10.1016/j.tiv.2023.105641. Epub 2023 Jul 10. PMID: 37437822.

• Bourgois, A., D. Saurat, S. De Araujo, A. Boyard, N. Guitard, S. Renault, F. Fargeau, C. Frederic, E. Peyret, E. Flahaut, A. Servonnet, A. L. Favier, G. Lacroix, S. François and S. Dekali. Nose-only inhalations of high-dose alumina nanoparticles/hydrogen chloride gas mixtures induce strong pulmonary pro-inflammatory response: a pilot study. Inhal Toxicol, 2021, 1-17.

• Nelissen I, Haase A, Anguissola S, Rocks L, Jacobs A, Willems H, Riebeling, C, Luch, A, Piret, J. P., Toussaint, O., Trouiller, B., Lacroix, G., Gutleb, A. C. et al. Improving Quality in Nanoparticle-Induced Cytotoxicity Testing by a Tiered Inter-Laboratory Comparison Study. Nanomaterials (Basel, Switzerland). 2020;10(8).

• Lacroix G, Koch Wolfgang, Ritter D, Gutleb AC et al. Air-Liquid Interface In Vitro Models for Respiratory Toxicology Research: Consensus Workshop and Recommendations. Appl in vitro Toxicol, 2018, 4(2): 91-106. doi: 10.1089/aivt.2017.0034

• Loret T.; Rogerieux F.; Trouiller B.; Braun A.; Egles C.; Lacroix G. Predicting the in vivo pulmonary toxicity induced by acute exposure to poorly soluble nanomaterials by using advanced in vitro methods. Part Fibre Toxicol, 2018 Jun 4 2018;15(1). doi:10.1186/s12989-018-0260-6

• Relier C, Dubreuil M, Lozano Garcìa O, Cordelli E, Mejia J, Eleuteri P, Robidel F, Loret T, Pacchierotti F, Lucas S, Lacroix G, Trouiller B. Study of TiO2 P25 Nanoparticles Genotoxicity on Lung, Blood, and Liver Cells in Lung Overload and Non-Overload Conditions After Repeated Respiratory Exposure in Rats. Toxicol Sci. 2017 Apr 1;156(2):527-537. doi: 10.1093/toxsci/kfx006

• Loret T, Peyret E, Dubreuil M, Aguerre-Chariol O, Bressot C, le Bihan O, Amodeo T, Trouiller B, Braun A, Egles C, Lacroix G. Air-liquid interface exposure to aerosols of poorly soluble nanomaterials induces different biological activation levels compared to exposure to suspensions. Part Fibre Toxicol. 2016 Nov 3;13(1):58

• Hanot-Roy M, Tubeuf E, Guilbert A, Bado-Nilles A, Vigneron P, Trouiller B, Braun A, Lacroix G. Oxidative stress pathways involved in cytotoxicity and genotoxicity of titanium dioxide (TiO2) nanoparticles on cells constitutive of alveolo-capillary barrier in vitro. Toxicol In Vitro. 2016 Jun;33:125-35. doi: 10.1016/j.tiv.2016.01.013. Epub 2016 Feb 27.