Marc Codaccioni
Contact
PhD Project
There are numerous studies which have linked fetal exposure to chemical substances and health effects on children (e.g. slow fetal growth, or cognitive effects, or reproductive effects). The aim of the thesis will be to assess fetal exposure to different kind of chemicals thanks to Physiologically Based PharmacoKinetic (PBPK). This work will provide a better understanding of the link between pregnant women exposure and potential effects in child.
Work experience
Oct 2016 – Oct 2019. Doctor of Philosophy candidate at INERIS. Unity Models for Ecotoxicology and Toxicology. Subject: “Assessment of fetal exposure to chemical substances with Physiologically Based PharmacoKinetic (PBPK). Application to biomonitoring studies.”. Under the direction of Céline Brochot and Florence Zeman.
June – Sept 2016. Hospital research engineer at AP-HP. Clinical Pharmacology department at Cochin hospital.
Nov 2015 – June 2016. Internship in research team. Unity EA7323 Therapeutic assessment and perinatal and pediatric pharmacology. Subject: “Pharmacokinetic modeling of an antiepileptic drug for therapeutic drug monitoring”.
March – August 2015. Internship at Technologie Servier. Pharmacokinetic department. Subject: “Application of Population Pharmacokinetic approach in Wistar rats.”
July – August 2014. Internship in CNRS research team. Unity UMR 8203, vectorology and oncology therapy. Subject: “Validation of an analytical method for Cyclophosphamide and its metabolite 4OH-CPM by liquid chromatography coupled with tandem mass spectrometry in mouse plasma for pharmacological activity”.
Sept 2013 – Feb 2014. Pharmaceutical Clerkship at Gustave Roussy Institute. Quality control in pharmacology department.
July – August 2012. Internship in Inserm research team. Unity Inserm 770: Hemostasis and vascular cells dynamic. Subject: “Platelet microparticles and maintenance of vascular integrity during inflammation: involvement in vascular permeability”.
Education and training
Expected in 2019. AgroParisTech. Doctor of Philosophy. Subject: “Assessment of fetal exposure to chemical substances with Physiologically Based PharmacoKinetic (PBPK). Application to biomonitoring studies.”
Expected in 2016. Pharmacy Faculty Paris Sud. Pharmaciae Doctor. Subject: “Pharmacokinetic modeling of an antiepileptic drug for therapeutic drug monitoring”.
2015 – 2016. Faculty of Medicine Paris Sud. MSC in Public Health: “Methodology and statistics in biomedical research”.
2014 – 2015. Pharmacy Faculty Paris Descartes. MSC in Pharmacokinetic modeling.
2008 – 2015. Pharmacy Faculty Paris Sud. Specialization in Industry & Research.
Language skills and Sofware
Language
French: Native language
English: Operational skills
Spanish: Basic elements of language
Software
R,Monolix, NONMEM, WinNonlin, GNU MCSim